ADO
UniProt ID: Q96SZ5
Entrez ID: 84890
Protein name: 2-aminoethanethiol dioxygenase (EC 1.13.11.19) (Cysteamine dioxygenase)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Plays a vital role in regulating thiol metabolism and preserving oxygen homeostasis by oxidizing the sulfur of cysteamine and N-terminal cysteine-containing proteins to their corresponding sulfinic acids using O2 as a cosubstrate (PubMed:17581819, PubMed:29752763, PubMed:31273118, PubMed:3...
FUNCTION: Plays a vital role in regulating thiol metabolism and preserving oxygen homeostasis by oxidizing the sulfur of cysteamine and N-terminal cysteine-containing proteins to their corresponding sulfinic acids using O2 as a cosubstrate (PubMed:17581819, PubMed:29752763, PubMed:31273118, PubMed:32601061). Catalyzes the oxidation of cysteamine (2-aminoethanethiol) to hypotaurine (PubMed:17581819, PubMed:29752763, PubMed:32601061). Catalyzes the oxidation of regulators of G-protein signaling 4 (RGS4) and 5 (RGS5) and interleukin-32 (IL32) (PubMed:31273118, PubMed:32601061). {ECO:0000269|PubMed:17581819, ECO:0000269|PubMed:29752763, ECO:0000269|PubMed:31273118, ECO:0000269|PubMed:32601061}.
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GO - Biological processes (BP):
...
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GO - Molecular function (MF):
cysteamine dioxygenase activity [GO:0047800]; metal ion binding [GO:0046872]...
cysteamine dioxygenase activity [GO:0047800]; metal ion binding [GO:0046872]
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GO - Cellular component (CC):
cytosol [GO:0005829]...
cytosol [GO:0005829]
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ADO
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*NOTE: the Kaplan plots were collected from OncoLnc