DegronMD - Q96T51(RUFY1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M110I	TCGA-GN-A26C	SKCM	TCGA	DSGDGT	DEG_SCF_TRCP1_1	95:100	Mutation rewiring degron network	0.0556
p.R100Q	DO1464	BRCA	ICGC	DSGDGT	DEG_SCF_TRCP1_1	95:100	Mutation altering degron motif	0.7329
p.V86F	DO229045	LICA	ICGC	DSGDGT	DEG_SCF_TRCP1_1	95:100	Mutation rewiring degron network	0.0833
p.A101V	DO47903	STAD	ICGC	DSGDGT	DEG_SCF_TRCP1_1	95:100	Mutation rewiring degron network	0.3056
p.A101V	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGDGT	DEG_SCF_TRCP1_1	95:100	Mutation rewiring degron network	0.3056
p.A101V	SNU-1040	large intestine	COSMIC	DSGDGT	DEG_SCF_TRCP1_1	95:100	Mutation rewiring degron network	0.3056
p.Q108H	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	DSGDGT	DEG_SCF_TRCP1_1	95:100	Mutation rewiring degron network	0.1111
p.C107S	SIDM00503	Gastric Carcinoma	GDSC	DSGDGT	DEG_SCF_TRCP1_1	95:100	Mutation rewiring degron network	0.1389
p.C107S	SIDM00274	Gastric Carcinoma	GDSC	DSGDGT	DEG_SCF_TRCP1_1	95:100	Mutation rewiring degron network	0.1389
p.C107S	SIDM00302	Other Solid Cancers	GDSC	DSGDGT	DEG_SCF_TRCP1_1	95:100	Mutation rewiring degron network	0.1389
p.C107S	ACH-000047	Gastric Cancer	CCLE	DSGDGT	DEG_SCF_TRCP1_1	95:100	Mutation rewiring degron network	0.1389
p.C107S	ACH-000633	Gastric Cancer	CCLE	DSGDGT	DEG_SCF_TRCP1_1	95:100	Mutation rewiring degron network	0.1389
p.C107S	ACH-002149	Ovarian Cancer	CCLE	DSGDGT	DEG_SCF_TRCP1_1	95:100	Mutation rewiring degron network	0.1389
p.C107S	KGN	ovary	COSMIC	DSGDGT	DEG_SCF_TRCP1_1	95:100	Mutation rewiring degron network	0.1389
p.C107S	FU97	stomach	COSMIC	DSGDGT	DEG_SCF_TRCP1_1	95:100	Mutation rewiring degron network	0.1389
p.C107S	GCIY	stomach	COSMIC	DSGDGT	DEG_SCF_TRCP1_1	95:100	Mutation rewiring degron network	0.1389
p.E91K	ACH-000809	Esophageal Cancer	CCLE	DSGDGT	DEG_SCF_TRCP1_1	95:100	Mutation rewiring degron network	0.2222
p.E91K	KYSE-410	oesophagus	COSMIC	DSGDGT	DEG_SCF_TRCP1_1	95:100	Mutation rewiring degron network	0.2222
p.A101T	ACH-000961	Endometrial/Uterine Cancer	CCLE	DSGDGT	DEG_SCF_TRCP1_1	95:100	Mutation rewiring degron network	0.3056
p.L105I	ACH-001864	Bile Duct Cancer	CCLE	DSGDGT	DEG_SCF_TRCP1_1	95:100	Mutation rewiring degron network	0.1944

Kaplan plot for RUFY1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RUFY1

UniProt ID: Q96T51

Entrez ID: 80230

Protein name: RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (La-binding protein 1) (Rab4-interacting protein) (Zinc finger FYVE domain-containing protein 12)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for RUFY1 in