DegronMD

Uniprot ID: Q96T51

Source protein: RUN and FYVE domain-containing protein 1

Source gene: RUFY1

Class: DEG_SCF_TRCP1_1

Location: 95:100

E3 ligase: BTRC

DEGRON score: 0.9595

ASA_SCORE: 81.0333

COIL: 0.7852

CONS_SCORE: 0.3017

DSS_SCORE: 0.3918

HELIX: 0.2022

FCONS_SCORE: 1.0654

RIG_SCORE: 0.596

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M110I	TCGA-GN-A26C	SKCM	TCGA	DSGDGT	DEG_SCF_TRCP1_1	0.0556
p.R100Q	DO1464	BRCA	ICGC	DSGDGT	DEG_SCF_TRCP1_1	0.7329
p.V86F	DO229045	LICA	ICGC	DSGDGT	DEG_SCF_TRCP1_1	0.0833
p.A101V	DO47903	STAD	ICGC	DSGDGT	DEG_SCF_TRCP1_1	0.3056
p.A101V	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGDGT	DEG_SCF_TRCP1_1	0.3056
p.A101V	SNU-1040	large_intestine	COSMIC	DSGDGT	DEG_SCF_TRCP1_1	0.3056
p.Q108H	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	DSGDGT	DEG_SCF_TRCP1_1	0.1111
p.C107S	SIDM00503	Gastric Carcinoma	GDSC	DSGDGT	DEG_SCF_TRCP1_1	0.1389
p.C107S	SIDM00274	Gastric Carcinoma	GDSC	DSGDGT	DEG_SCF_TRCP1_1	0.1389
p.C107S	SIDM00302	Other Solid Cancers	GDSC	DSGDGT	DEG_SCF_TRCP1_1	0.1389
p.C107S	ACH-000047	Gastric Cancer	CCLE	DSGDGT	DEG_SCF_TRCP1_1	0.1389
p.C107S	ACH-000633	Gastric Cancer	CCLE	DSGDGT	DEG_SCF_TRCP1_1	0.1389
p.C107S	ACH-002149	Ovarian Cancer	CCLE	DSGDGT	DEG_SCF_TRCP1_1	0.1389
p.C107S	KGN	ovary	COSMIC	DSGDGT	DEG_SCF_TRCP1_1	0.1389
p.C107S	FU97	stomach	COSMIC	DSGDGT	DEG_SCF_TRCP1_1	0.1389
p.C107S	GCIY	stomach	COSMIC	DSGDGT	DEG_SCF_TRCP1_1	0.1389
p.E91K	ACH-000809	Esophageal Cancer	CCLE	DSGDGT	DEG_SCF_TRCP1_1	0.2222
p.E91K	KYSE-410	oesophagus	COSMIC	DSGDGT	DEG_SCF_TRCP1_1	0.2222
p.A101T	ACH-000961	Endometrial/Uterine Cancer	CCLE	DSGDGT	DEG_SCF_TRCP1_1	0.3056
p.L105I	ACH-001864	Bile Duct Cancer	CCLE	DSGDGT	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96T51	RUN and FYVE domain-containing protein 1	DEG_SCF_TRCP1_1	95:100	DSGDGT	BTRC	0.9595	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons