DegronMD - Q96T66(NMNAT3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q117R	TCGA-05-4250	LUAD	TCGA	STPAAVPEL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.1944
p.Q117R	YAPC	pancreas	COSMIC	STPAAVPEL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.1944
p.P135Q	TCGA-06-0645	GBM	TCGA	STPAAVPEL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.1944
p.A140T	TCGA-2W-A8YY	CESC	TCGA	STPAAVPEL	DEG_COP1_1	122:130	Mutation substituting flanking lysine	0.1667
p.L125V	TCGA-A5-A0G2	UCEC	TCGA	STPAAVPEL	DEG_COP1_1	122:130	Mutation altering degron motif	0.6765
p.L125S	TCGA-AX-A1CE	UCEC	TCGA	STPAAVPEL	DEG_COP1_1	122:130	Mutation altering degron motif	0.7667
p.A114T	TCGA-B5-A3FA	UCEC	TCGA	STPAAVPEL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.1111
p.V128M	TCGA-BR-4280	STAD	TCGA	STPAAVPEL	DEG_COP1_1	122:130	Mutation altering degron motif	0.7208
p.D134N	TCGA-W3-AA1W	SKCM	TCGA	STPAAVPEL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.2222
p.G113S	DO48505	LIHC	ICGC	STPAAVPEL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.0833
p.E129K	DO231524	LINC	ICGC	STPAAVPEL	DEG_COP1_1	122:130	Mutation altering degron motif	0.7022
p.P124T	DO26602	LUSC	ICGC	STPAAVPEL	DEG_COP1_1	122:130	Mutation altering degron motif	0.5919
p.A126V	DO42312	UCEC	ICGC	STPAAVPEL	DEG_COP1_1	122:130	Mutation altering degron motif	0.5825
p.G135A	DO43162	UCEC	ICGC	STPAAVPEL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.1944
p.H116R	DO41752	UCEC	ICGC	STPAAVPEL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.1667
p.V138I	DO41235	UCEC	ICGC	STPAAVPEL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.1111
p.V138I	ACH-001518	Endometrial/Uterine Cancer	CCLE	STPAAVPEL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.1111
p.R128Q	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	STPAAVPEL	DEG_COP1_1	122:130	Mutation altering degron motif	0.7329
p.R128Q	EMC-BAC-1	lung	COSMIC	STPAAVPEL	DEG_COP1_1	122:130	Mutation altering degron motif	0.7329
p.L129H	SIDM00968	Ovarian Carcinoma	GDSC	STPAAVPEL	DEG_COP1_1	122:130	Mutation altering degron motif	0.7313
p.Q119R	SIDM00537	Colorectal Carcinoma	GDSC	STPAAVPEL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.25
p.Q119R	GP5d	large intestine	COSMIC	STPAAVPEL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.25
p.R128P	SIDM01111	Ewing's Sarcoma	GDSC	STPAAVPEL	DEG_COP1_1	122:130	Mutation altering degron motif	0.7512
p.R128P	SK-ES-1	bone	COSMIC	STPAAVPEL	DEG_COP1_1	122:130	Mutation altering degron motif	0.7512
p.A125T	ACH-000131	Non-Cancerous	CCLE	STPAAVPEL	DEG_COP1_1	122:130	Mutation altering degron motif	0.6028
p.T114I	SNU-1040	large intestine	COSMIC	STPAAVPEL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.1111
p.G132C	DU-145	prostate	COSMIC	STPAAVPEL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.2778
p.K139E	EKVX	lung	COSMIC	STPAAVPEL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.0833
p.V134A	SNU-1040	large intestine	COSMIC	STPAAVPEL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.2222
p.V134D	NCI-H650	lung	COSMIC	STPAAVPEL	DEG_COP1_1	122:130	Mutation rewiring degron network	0.2222
p.L129V	RERF-LC-Sq1	lung	COSMIC	STPAAVPEL	DEG_COP1_1	122:130	Mutation altering degron motif	0.6765

Kaplan plot for NMNAT3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NMNAT3

UniProt ID: Q96T66

Entrez ID: 349565

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NMNAT3 in