DegronMD

Uniprot ID: Q96T66

Source protein: Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3

Source gene: NMNAT3

Class: DEG_COP1_1

Location: 122:130

E3 ligase: COP1

DEGRON score: 0.8295

ASA_SCORE: 57.3222

COIL: 0.7548

CONS_SCORE: 0.2917

DSS_SCORE: 0.2439

HELIX: 0.0558

FCONS_SCORE: 0.6017

RIG_SCORE: 0.7817

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q117R	TCGA-05-4250	LUAD	TCGA	STPAAVPEL	DEG_COP1_1	0.1944
p.Q117R	YAPC	pancreas	COSMIC	STPAAVPEL	DEG_COP1_1	0.1944
p.P135Q	TCGA-06-0645	GBM	TCGA	STPAAVPEL	DEG_COP1_1	0.1944
p.A140T	TCGA-2W-A8YY	CESC	TCGA	STPAAVPEL	DEG_COP1_1	0.1667
p.L125V	TCGA-A5-A0G2	UCEC	TCGA	STPAAVPEL	DEG_COP1_1	0.6765
p.L125S	TCGA-AX-A1CE	UCEC	TCGA	STPAAVPEL	DEG_COP1_1	0.7667
p.A114T	TCGA-B5-A3FA	UCEC	TCGA	STPAAVPEL	DEG_COP1_1	0.1111
p.V128M	TCGA-BR-4280	STAD	TCGA	STPAAVPEL	DEG_COP1_1	0.7208
p.D134N	TCGA-W3-AA1W	SKCM	TCGA	STPAAVPEL	DEG_COP1_1	0.2222
p.G113S	DO48505	LIHC	ICGC	STPAAVPEL	DEG_COP1_1	0.0833
p.E129K	DO231524	LINC	ICGC	STPAAVPEL	DEG_COP1_1	0.7022
p.P124T	DO26602	LUSC	ICGC	STPAAVPEL	DEG_COP1_1	0.5919
p.A126V	DO42312	UCEC	ICGC	STPAAVPEL	DEG_COP1_1	0.5825
p.G135A	DO43162	UCEC	ICGC	STPAAVPEL	DEG_COP1_1	0.1944
p.H116R	DO41752	UCEC	ICGC	STPAAVPEL	DEG_COP1_1	0.1667
p.V138I	DO41235	UCEC	ICGC	STPAAVPEL	DEG_COP1_1	0.1111
p.V138I	ACH-001518	Endometrial/Uterine Cancer	CCLE	STPAAVPEL	DEG_COP1_1	0.1111
p.R128Q	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	STPAAVPEL	DEG_COP1_1	0.7329
p.R128Q	EMC-BAC-1	lung	COSMIC	STPAAVPEL	DEG_COP1_1	0.7329
p.L129H	SIDM00968	Ovarian Carcinoma	GDSC	STPAAVPEL	DEG_COP1_1	0.7313
p.Q119R	SIDM00537	Colorectal Carcinoma	GDSC	STPAAVPEL	DEG_COP1_1	0.25
p.Q119R	GP5d	large_intestine	COSMIC	STPAAVPEL	DEG_COP1_1	0.25
p.R128P	SIDM01111	Ewing's Sarcoma	GDSC	STPAAVPEL	DEG_COP1_1	0.7512
p.R128P	SK-ES-1	bone	COSMIC	STPAAVPEL	DEG_COP1_1	0.7512
p.A125T	ACH-000131	Non-Cancerous	CCLE	STPAAVPEL	DEG_COP1_1	0.6028
p.T114I	SNU-1040	large_intestine	COSMIC	STPAAVPEL	DEG_COP1_1	0.1111
p.G132C	DU-145	prostate	COSMIC	STPAAVPEL	DEG_COP1_1	0.2778
p.K139E	EKVX	lung	COSMIC	STPAAVPEL	DEG_COP1_1	0.0833
p.V134A	SNU-1040	large_intestine	COSMIC	STPAAVPEL	DEG_COP1_1	0.2222
p.V134D	NCI-H650	lung	COSMIC	STPAAVPEL	DEG_COP1_1	0.2222
p.L129V	RERF-LC-Sq1	lung	COSMIC	STPAAVPEL	DEG_COP1_1	0.6765

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: STPAAVPEL

Degron related mutations and impact score

Drug responses associated with NMNAT3 mutations

All proteins holding degron of STPAAVPEL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96T66	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3	DEG_COP1_1	122:130	STPAAVPEL	COP1	0.8295	More...