DegronMD - Q99442(SEC62)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V243A	TCGA-AZ-4315	COAD	TCGA	ARCILFLII	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.3056
p.V243A	DO8842	COAD	ICGC	ARCILFLII	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.3056
p.A244S	TCGA-B5-A1MX	UCEC	TCGA	ARCILFLII	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.6477
p.A244S	DO41999	UCEC	ICGC	ARCILFLII	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.6477
p.L250I	TCGA-D1-A17Q	UCEC	TCGA	ARCILFLII	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.6063
p.L250I	DO41903	UCEC	ICGC	ARCILFLII	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.6063
p.L239I	DO222762	COCA	ICGC	ARCILFLII	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.1944
p.H260Y	DO233623	GACA	ICGC	ARCILFLII	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.1111
p.A242V	ACH-001063	Ovarian Cancer	CCLE	ARCILFLII	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons