DegronMD

Uniprot ID: Q99442

Source protein: Translocation protein SEC62

Source gene: SEC62

Class: DEG_APCC_DBOX_1

Location: 244:252

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8521

ASA_SCORE: 81.0556

COIL: 0.0771

CONS_SCORE: 0.5998

DSS_SCORE: 0.0001

HELIX: 0.9149

FCONS_SCORE: 1.2124

RIG_SCORE: 1.1812

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V243A	TCGA-AZ-4315	COAD	TCGA	ARCILFLII	DEG_APCC_DBOX_1	0.3056
p.V243A	DO8842	COAD	ICGC	ARCILFLII	DEG_APCC_DBOX_1	0.3056
p.A244S	TCGA-B5-A1MX	UCEC	TCGA	ARCILFLII	DEG_APCC_DBOX_1	0.6477
p.A244S	DO41999	UCEC	ICGC	ARCILFLII	DEG_APCC_DBOX_1	0.6477
p.L250I	TCGA-D1-A17Q	UCEC	TCGA	ARCILFLII	DEG_APCC_DBOX_1	0.6063
p.L250I	DO41903	UCEC	ICGC	ARCILFLII	DEG_APCC_DBOX_1	0.6063
p.L239I	DO222762	COCA	ICGC	ARCILFLII	DEG_APCC_DBOX_1	0.1944
p.H260Y	DO233623	GACA	ICGC	ARCILFLII	DEG_APCC_DBOX_1	0.1111
p.A242V	ACH-001063	Ovarian Cancer	CCLE	ARCILFLII	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99442	Translocation protein SEC62	DEG_APCC_DBOX_1	244:252	ARCILFLII	APC,CDC20,FZR1	0.8521	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons