DegronMD - Q99456(KRT12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S18F	TCGA-14-0812	GBM	TCGA	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation altering degron motif	0.7982
p.S18F	DO12256	GBM	ICGC	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation altering degron motif	0.7982
p.S23W	TCGA-24-1565	OV	TCGA	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.1944
p.S23W	DO31719	OV	ICGC	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.1944
p.I27T	TCGA-99-7458	LUAD	TCGA	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.0833
p.I27T	DO25416	LUAD	ICGC	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.0833
p.S18T	TCGA-CV-7568	HNSC	TCGA	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation altering degron motif	0.6005
p.S18T	DO14160	HNSC	ICGC	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation altering degron motif	0.6005
p.G28C	TCGA-DF-A2KU	UCEC	TCGA	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.0556
p.G28C	DO223286	UCEC	ICGC	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.0556
p.S9L	TCGA-ER-A19M	SKCM	TCGA	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.25
p.S9L	DO37798	SKCM	ICGC	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.25
p.R13H	TCGA-EY-A549	UCEC	TCGA	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation altering degron motif	0.7133
p.R13H	TCGA-G4-6298	COAD	TCGA	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation altering degron motif	0.7133
p.R13H	DO7834	COAD	ICGC	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation altering degron motif	0.7133
p.R13H	DO48174	UCEC	ICGC	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation altering degron motif	0.7133
p.P15S	DO228483	BRCA	ICGC	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation altering degron motif	0.6752
p.P15S	DO229013	COCA	ICGC	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation altering degron motif	0.6752
p.P15S	DO229016	COCA	ICGC	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation altering degron motif	0.6752
p.P15S	DO229005	COCA	ICGC	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation altering degron motif	0.6752
p.P15S	DO230990	LUSC	ICGC	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation altering degron motif	0.6752
p.R20W	DO227999	COCA	ICGC	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.2778
p.R20W	DO229010	COCA	ICGC	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.2778
p.G28R	DO47004	RECA	ICGC	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.0556
p.R13C	SIDM00980	Gastric Carcinoma	GDSC	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation altering degron motif	0.719
p.R13C	ACH-000948	Gastric Cancer	CCLE	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation altering degron motif	0.719
p.R13C	23132-87	stomach	COSMIC	VRTPGLS	DEG_SCF_FBW7_1	12:18	Mutation altering degron motif	0.719

Kaplan plot for KRT12 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KRT12

UniProt ID: Q99456

Entrez ID: 3859

Protein name: Keratin, type I cytoskeletal 12 (Cytokeratin-12) (CK-12) (Keratin-12) (K12)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KRT12 in