DegronMD

Uniprot ID: Q99456

Source protein: Keratin, type I cytoskeletal 12

Source gene: KRT12

Class: DEG_SCF_FBW7_1

Location: 12:18

E3 ligase: FBXW7

DEGRON score: 0.99

ASA_SCORE: 87.4571

COIL: 0.775

CONS_SCORE: 0.3395

DSS_SCORE: 0.53

HELIX: 0.0216

FCONS_SCORE: 1.4017

RIG_SCORE: 0.7148

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S18F	TCGA-14-0812	GBM	TCGA	VRTPGLS	DEG_SCF_FBW7_1	0.7982
p.S18F	DO12256	GBM	ICGC	VRTPGLS	DEG_SCF_FBW7_1	0.7982
p.S23W	TCGA-24-1565	OV	TCGA	VRTPGLS	DEG_SCF_FBW7_1	0.1944
p.S23W	DO31719	OV	ICGC	VRTPGLS	DEG_SCF_FBW7_1	0.1944
p.I27T	TCGA-99-7458	LUAD	TCGA	VRTPGLS	DEG_SCF_FBW7_1	0.0833
p.I27T	DO25416	LUAD	ICGC	VRTPGLS	DEG_SCF_FBW7_1	0.0833
p.S18T	TCGA-CV-7568	HNSC	TCGA	VRTPGLS	DEG_SCF_FBW7_1	0.6005
p.S18T	DO14160	HNSC	ICGC	VRTPGLS	DEG_SCF_FBW7_1	0.6005
p.G28C	TCGA-DF-A2KU	UCEC	TCGA	VRTPGLS	DEG_SCF_FBW7_1	0.0556
p.G28C	DO223286	UCEC	ICGC	VRTPGLS	DEG_SCF_FBW7_1	0.0556
p.S9L	TCGA-ER-A19M	SKCM	TCGA	VRTPGLS	DEG_SCF_FBW7_1	0.25
p.S9L	DO37798	SKCM	ICGC	VRTPGLS	DEG_SCF_FBW7_1	0.25
p.R13H	TCGA-EY-A549	UCEC	TCGA	VRTPGLS	DEG_SCF_FBW7_1	0.7133
p.R13H	TCGA-G4-6298	COAD	TCGA	VRTPGLS	DEG_SCF_FBW7_1	0.7133
p.R13H	DO7834	COAD	ICGC	VRTPGLS	DEG_SCF_FBW7_1	0.7133
p.R13H	DO48174	UCEC	ICGC	VRTPGLS	DEG_SCF_FBW7_1	0.7133
p.P15S	DO228483	BRCA	ICGC	VRTPGLS	DEG_SCF_FBW7_1	0.6752
p.P15S	DO229013	COCA	ICGC	VRTPGLS	DEG_SCF_FBW7_1	0.6752
p.P15S	DO229016	COCA	ICGC	VRTPGLS	DEG_SCF_FBW7_1	0.6752
p.P15S	DO229005	COCA	ICGC	VRTPGLS	DEG_SCF_FBW7_1	0.6752
p.P15S	DO230990	LUSC	ICGC	VRTPGLS	DEG_SCF_FBW7_1	0.6752
p.R20W	DO227999	COCA	ICGC	VRTPGLS	DEG_SCF_FBW7_1	0.2778
p.R20W	DO229010	COCA	ICGC	VRTPGLS	DEG_SCF_FBW7_1	0.2778
p.G28R	DO47004	RECA	ICGC	VRTPGLS	DEG_SCF_FBW7_1	0.0556
p.R13C	SIDM00980	Gastric Carcinoma	GDSC	VRTPGLS	DEG_SCF_FBW7_1	0.719
p.R13C	ACH-000948	Gastric Cancer	CCLE	VRTPGLS	DEG_SCF_FBW7_1	0.719
p.R13C	23132-87	stomach	COSMIC	VRTPGLS	DEG_SCF_FBW7_1	0.719

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99456	Keratin, type I cytoskeletal 12	DEG_SCF_FBW7_1	12:18	VRTPGLS	FBXW7	0.99	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons