DegronMD - Q99502(EYA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G39D	TCGA-13-0883	OV	TCGA	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation altering degron motif	0.6087
p.G39D	TCGA-WQ-A9G7	LIHC	TCGA	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation altering degron motif	0.6087
p.G39D	DO52326	LIHC	ICGC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation altering degron motif	0.6087
p.G39D	DO28711	OV	ICGC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation altering degron motif	0.6087
p.S50C	TCGA-44-6774	LUAD	TCGA	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.0556
p.G26C	TCGA-90-A4ED	LUSC	TCGA	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.0833
p.G26C	DO45482	LUSC	ICGC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.0833
p.E41K	TCGA-AX-A2HC	UCEC	TCGA	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.3056
p.E41K	TCGA-GF-A6C9	SKCM	TCGA	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.3056
p.E41K	DO218856	SKCA	ICGC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.3056
p.E41K	DO51254	SKCM	ICGC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.3056
p.E41K	DO41572	UCEC	ICGC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.3056
p.P37L	TCGA-EO-A22U	UCEC	TCGA	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation altering degron motif	0.7582
p.P37L	DO228011	SKCA	ICGC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation altering degron motif	0.7582
p.P37L	DO43755	UCEC	ICGC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation altering degron motif	0.7582
p.S34F	TCGA-EO-A22U	UCEC	TCGA	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.3056
p.S34F	DO43755	UCEC	ICGC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.3056
p.G26D	TCGA-OD-A75X	SKCM	TCGA	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.0833
p.G26D	DO48601	SKCM	ICGC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.0833
p.N38S	TCGA-RP-A693	SKCM	TCGA	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation altering degron motif	0.5958
p.N38S	DO51268	SKCM	ICGC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation altering degron motif	0.5958
p.R44Q	DO48445	BLCA	ICGC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.2222
p.R44Q	DO40884	UCEC	ICGC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.2222
p.S28T	DO225105	BRCA	ICGC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.1389
p.D25N	DO222746	COCA	ICGC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.0556
p.D25N	DO43602	UCEC	ICGC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.0556
p.D25N	DO43755	UCEC	ICGC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.0556
p.A35E	DO48310	ESCA	ICGC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation altering degron motif	0.7701
p.F31L	DO233207	GACA	ICGC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.2222
p.F31L	DO47769	STAD	ICGC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.2222
p.F31L	DO41758	UCEC	ICGC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.2222
p.P45L	DO222702	MELA	ICGC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.1944
p.P43L	DO37406	SKCM	ICGC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation substituting flanking lysine	0.3611
p.G26E	DO37444	SKCM	ICGC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.0833
p.S39G	DO38404	STAD	ICGC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation altering degron motif	0.6993
p.H29Y	SIDM00627	Cervical Carcinoma	GDSC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.1667
p.H29Y	ACH-000490	Cervical Cancer	CCLE	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.1667
p.H29Y	ACH-001359	Cervical Cancer	CCLE	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.1667
p.H29Y	ME-180	cervix	COSMIC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.1667
p.K43R	SIDM00683	Prostate Carcinoma	GDSC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation substituting flanking lysine	0.3611
p.K43R	ACH-000977	lymph node	CCLE	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation substituting flanking lysine	0.3611
p.K43R	LNCaP-Clone-FGC	prostate	COSMIC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation substituting flanking lysine	0.3611
p.P38L	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation altering degron motif	0.7582
p.P38L	CHL-1	skin	COSMIC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation altering degron motif	0.7582
p.G37V	JHH-1	liver	COSMIC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation altering degron motif	0.7532
p.G26W	H513	pleura	COSMIC	MTPNGT	DEG_SCF_FBW7_1	35:40	Mutation rewiring degron network	0.0833

Kaplan plot for EYA1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EYA1

UniProt ID: Q99502

Entrez ID: 2138

Protein name: Eyes absent homolog 1 (EC 3.1.3.16) (EC 3.1.3.48)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EYA1 in