DegronMD

Uniprot ID: Q99502

Source protein: Eyes absent homolog 1

Source gene: EYA1

Class: DEG_SCF_FBW7_1

Location: 35:40

E3 ligase: FBXW7

DEGRON score: 0.9952

ASA_SCORE: 68.35

COIL: 0.864

CONS_SCORE: 0.3366

DSS_SCORE: 0.7244

HELIX: 0.0393

FCONS_SCORE: 1.1591

RIG_SCORE: 0.5813

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G39D	TCGA-13-0883	OV	TCGA	MTPNGT	DEG_SCF_FBW7_1	0.6087
p.G39D	TCGA-WQ-A9G7	LIHC	TCGA	MTPNGT	DEG_SCF_FBW7_1	0.6087
p.G39D	DO52326	LIHC	ICGC	MTPNGT	DEG_SCF_FBW7_1	0.6087
p.G39D	DO28711	OV	ICGC	MTPNGT	DEG_SCF_FBW7_1	0.6087
p.S50C	TCGA-44-6774	LUAD	TCGA	MTPNGT	DEG_SCF_FBW7_1	0.0556
p.G26C	TCGA-90-A4ED	LUSC	TCGA	MTPNGT	DEG_SCF_FBW7_1	0.0833
p.G26C	DO45482	LUSC	ICGC	MTPNGT	DEG_SCF_FBW7_1	0.0833
p.E41K	TCGA-AX-A2HC	UCEC	TCGA	MTPNGT	DEG_SCF_FBW7_1	0.3056
p.E41K	TCGA-GF-A6C9	SKCM	TCGA	MTPNGT	DEG_SCF_FBW7_1	0.3056
p.E41K	DO218856	SKCA	ICGC	MTPNGT	DEG_SCF_FBW7_1	0.3056
p.E41K	DO51254	SKCM	ICGC	MTPNGT	DEG_SCF_FBW7_1	0.3056
p.E41K	DO41572	UCEC	ICGC	MTPNGT	DEG_SCF_FBW7_1	0.3056
p.P37L	TCGA-EO-A22U	UCEC	TCGA	MTPNGT	DEG_SCF_FBW7_1	0.7582
p.P37L	DO228011	SKCA	ICGC	MTPNGT	DEG_SCF_FBW7_1	0.7582
p.P37L	DO43755	UCEC	ICGC	MTPNGT	DEG_SCF_FBW7_1	0.7582
p.S34F	TCGA-EO-A22U	UCEC	TCGA	MTPNGT	DEG_SCF_FBW7_1	0.3056
p.S34F	DO43755	UCEC	ICGC	MTPNGT	DEG_SCF_FBW7_1	0.3056
p.G26D	TCGA-OD-A75X	SKCM	TCGA	MTPNGT	DEG_SCF_FBW7_1	0.0833
p.G26D	DO48601	SKCM	ICGC	MTPNGT	DEG_SCF_FBW7_1	0.0833
p.N38S	TCGA-RP-A693	SKCM	TCGA	MTPNGT	DEG_SCF_FBW7_1	0.5958
p.N38S	DO51268	SKCM	ICGC	MTPNGT	DEG_SCF_FBW7_1	0.5958
p.R44Q	DO48445	BLCA	ICGC	MTPNGT	DEG_SCF_FBW7_1	0.2222
p.R44Q	DO40884	UCEC	ICGC	MTPNGT	DEG_SCF_FBW7_1	0.2222
p.S28T	DO225105	BRCA	ICGC	MTPNGT	DEG_SCF_FBW7_1	0.1389
p.D25N	DO222746	COCA	ICGC	MTPNGT	DEG_SCF_FBW7_1	0.0556
p.D25N	DO43602	UCEC	ICGC	MTPNGT	DEG_SCF_FBW7_1	0.0556
p.D25N	DO43755	UCEC	ICGC	MTPNGT	DEG_SCF_FBW7_1	0.0556
p.A35E	DO48310	ESCA	ICGC	MTPNGT	DEG_SCF_FBW7_1	0.7701
p.F31L	DO233207	GACA	ICGC	MTPNGT	DEG_SCF_FBW7_1	0.2222
p.F31L	DO47769	STAD	ICGC	MTPNGT	DEG_SCF_FBW7_1	0.2222
p.F31L	DO41758	UCEC	ICGC	MTPNGT	DEG_SCF_FBW7_1	0.2222
p.P45L	DO222702	MELA	ICGC	MTPNGT	DEG_SCF_FBW7_1	0.1944
p.P43L	DO37406	SKCM	ICGC	MTPNGT	DEG_SCF_FBW7_1	0.3611
p.G26E	DO37444	SKCM	ICGC	MTPNGT	DEG_SCF_FBW7_1	0.0833
p.S39G	DO38404	STAD	ICGC	MTPNGT	DEG_SCF_FBW7_1	0.6993
p.H29Y	SIDM00627	Cervical Carcinoma	GDSC	MTPNGT	DEG_SCF_FBW7_1	0.1667
p.H29Y	ACH-000490	Cervical Cancer	CCLE	MTPNGT	DEG_SCF_FBW7_1	0.1667
p.H29Y	ACH-001359	Cervical Cancer	CCLE	MTPNGT	DEG_SCF_FBW7_1	0.1667
p.H29Y	ME-180	cervix	COSMIC	MTPNGT	DEG_SCF_FBW7_1	0.1667
p.K43R	SIDM00683	Prostate Carcinoma	GDSC	MTPNGT	DEG_SCF_FBW7_1	0.3611
p.K43R	ACH-000977	lymph_node	CCLE	MTPNGT	DEG_SCF_FBW7_1	0.3611
p.K43R	LNCaP-Clone-FGC	prostate	COSMIC	MTPNGT	DEG_SCF_FBW7_1	0.3611
p.P38L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	MTPNGT	DEG_SCF_FBW7_1	0.7582
p.P38L	CHL-1	skin	COSMIC	MTPNGT	DEG_SCF_FBW7_1	0.7582
p.G37V	JHH-1	liver	COSMIC	MTPNGT	DEG_SCF_FBW7_1	0.7532
p.G26W	H513	pleura	COSMIC	MTPNGT	DEG_SCF_FBW7_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MTPNGT

Degron related mutations and impact score

Drug responses associated with EYA1 mutations

All proteins holding degron of MTPNGT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99502	Eyes absent homolog 1	DEG_SCF_FBW7_1	35:40	MTPNGT	FBXW7	0.9952	More...