DegronMD - Q99547(MPHOSPH6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y138D	TCGA-96-7544	LUSC	TCGA	NGDITPIK	DEG_SCF_SKP2-CKS1_1	143:150	Mutation rewiring degron network	0.1944
p.Y138D	DO26425	LUSC	ICGC	NGDITPIK	DEG_SCF_SKP2-CKS1_1	143:150	Mutation rewiring degron network	0.1944
p.D145A	TCGA-AX-A2HC	UCEC	TCGA	NGDITPIK	DEG_SCF_SKP2-CKS1_1	143:150	Mutation altering degron motif	0.7793
p.D145A	DO41572	UCEC	ICGC	NGDITPIK	DEG_SCF_SKP2-CKS1_1	143:150	Mutation altering degron motif	0.7793
p.K153N	TCGA-FD-A6TC	BLCA	TCGA	NGDITPIK	DEG_SCF_SKP2-CKS1_1	143:150	Mutation blocking ubiquitination signal	0.6944
p.K153N	DO49755	BLCA	ICGC	NGDITPIK	DEG_SCF_SKP2-CKS1_1	143:150	Mutation blocking ubiquitination signal	0.6944
p.K152R	DO52492	COCA	ICGC	NGDITPIK	DEG_SCF_SKP2-CKS1_1	143:150	Mutation rewiring degron network	0.2778
p.A136D	DO229006	LICA	ICGC	NGDITPIK	DEG_SCF_SKP2-CKS1_1	143:150	Mutation rewiring degron network	0.1389
p.A151G	SIDM01652	Non-Cancerous	GDSC	NGDITPIK	DEG_SCF_SKP2-CKS1_1	143:150	Mutation rewiring degron network	0.3056
p.A151G	SIDM00187	Kidney Carcinoma	GDSC	NGDITPIK	DEG_SCF_SKP2-CKS1_1	143:150	Mutation rewiring degron network	0.3056
p.A151G	ACH-002352	Non-Cancerous	CCLE	NGDITPIK	DEG_SCF_SKP2-CKS1_1	143:150	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons