DegronMD

Uniprot ID: Q99547

Source protein: M-phase phosphoprotein 6

Source gene: MPHOSPH6

Class: DEG_SCF_SKP2-CKS1_1

Location: 143:150

E3 ligase: SKP2,CSK1

DEGRON score: 0.9894

ASA_SCORE: 96.9125

COIL: 0.8468

CONS_SCORE: 0.3902

DSS_SCORE: 0.4774

HELIX: 0.1295

FCONS_SCORE: 0.7594

RIG_SCORE: 0.7659

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y138D	TCGA-96-7544	LUSC	TCGA	NGDITPIK	DEG_SCF_SKP2-CKS1_1	0.1944
p.Y138D	DO26425	LUSC	ICGC	NGDITPIK	DEG_SCF_SKP2-CKS1_1	0.1944
p.D145A	TCGA-AX-A2HC	UCEC	TCGA	NGDITPIK	DEG_SCF_SKP2-CKS1_1	0.7793
p.D145A	DO41572	UCEC	ICGC	NGDITPIK	DEG_SCF_SKP2-CKS1_1	0.7793
p.K153N	TCGA-FD-A6TC	BLCA	TCGA	NGDITPIK	DEG_SCF_SKP2-CKS1_1	0.6944
p.K153N	DO49755	BLCA	ICGC	NGDITPIK	DEG_SCF_SKP2-CKS1_1	0.6944
p.K152R	DO52492	COCA	ICGC	NGDITPIK	DEG_SCF_SKP2-CKS1_1	0.2778
p.A136D	DO229006	LICA	ICGC	NGDITPIK	DEG_SCF_SKP2-CKS1_1	0.1389
p.A151G	SIDM01652	Non-Cancerous	GDSC	NGDITPIK	DEG_SCF_SKP2-CKS1_1	0.3056
p.A151G	SIDM00187	Kidney Carcinoma	GDSC	NGDITPIK	DEG_SCF_SKP2-CKS1_1	0.3056
p.A151G	ACH-002352	Non-Cancerous	CCLE	NGDITPIK	DEG_SCF_SKP2-CKS1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99547	M-phase phosphoprotein 6	DEG_SCF_SKP2-CKS1_1	143:150	NGDITPIK	SKP2,CSK1	0.9894	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons