DegronMD - Q99572(P2RX7)

GO - Biological processes (BP): apoptotic signaling pathway [GO:0097190]; bleb assembly [GO:0032060]; calcium ion transmembrane transport [GO:0070588]; calcium-mediated signaling using extracellular calcium source [GO:0035585]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; cell surface receptor signaling pathway involved in cell-cell signaling [GO:1905114]; cellular response to ATP [GO:0071318]; cellular response to dsRNA [GO:0071359]; cellular response to extracellular stimulus [GO:0031668]; ceramide biosynthetic process [GO:0046513]; collagen metabolic process [GO:0032963]; defense response to Gram-positive bacterium [GO:0050830]; extrinsic apoptotic signaling pathway [GO:0097191]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response [GO:0006954]; membrane depolarization [GO:0051899]; membrane protein ectodomain proteolysis [GO:0006509]; mitochondrion organization [GO:0007005]; NAD transport [GO:0043132]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell volume [GO:0045794]; negative regulation of MAPK cascade [GO:0043409]; phagolysosome assembly [GO:0001845]; phospholipid transfer to membrane [GO:0006649]; plasma membrane phospholipid scrambling [GO:0017121]; pore complex assembly [GO:0046931]; positive regulation of bleb assembly [GO:1904172]; positive regulation of bone mineralization [GO:0030501]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cytoskeleton organization [GO:0051495]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of glycolytic process [GO:0045821]; positive regulation of interleukin-1 alpha production [GO:0032730]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of ion transmembrane transport [GO:0034767]; positive regulation of lymphocyte apoptotic process [GO:0070230]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of protein secretion [GO:0050714]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; protein catabolic process [GO:0030163]; protein phosphorylation [GO:0006468]; protein processing [GO:0016485]; purinergic nucleotide receptor signaling pathway [GO:0035590]; reactive oxygen species metabolic process [GO:0072593]; regulation of killing of cells of another organism [GO:0051709]; regulation of sodium ion transport [GO:0002028]; release of sequestered calcium ion into cytosol [GO:0051209]; response to ATP [GO:0033198]; response to calcium ion [GO:0051592]; response to electrical stimulus [GO:0051602]; response to fluid shear stress [GO:0034405]; response to ischemia [GO:0002931]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; sensory perception of pain [GO:0019233]; skeletal system morphogenesis [GO:0048705]; synaptic vesicle exocytosis [GO:0016079]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]; vesicle budding from membrane [GO:0006900] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E531K	TCGA-ZJ-AAXB	CESC	TCGA	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation altering degron motif	0.7022
p.E531K	DO219753	CESC	ICGC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation altering degron motif	0.7022
p.F525L	DO46370	OV	ICGC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.3056
p.H521Q	SIDM01265	Plasma Cell Myeloma	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.1944
p.H521Q	SIDM00773	Non-Cancerous	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.1944
p.H521Q	SIDM00845	Burkitt's Lymphoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.1944
p.H521Q	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.1944
p.H521Q	SIDM00969	Ovarian Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.1944
p.H521Q	SIDM00855	Other Sarcomas	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.1944
p.H521Q	SIDM00087	Plasma Cell Myeloma	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.1944
p.H521Q	SIDM00829	Acute Myeloid Leukemia	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.1944
p.H521Q	SIDM00633	Breast Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.1944
p.H521Q	SIDM00529	Breast Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.1944
p.H521Q	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.1944
p.H521Q	SIDM00863	Burkitt's Lymphoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.1944
p.H521Q	SIDM00721	Small Cell Lung Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.1944
p.H521Q	SIDM00774	Breast Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.1944
p.H521Q	SIDM00760	Small Cell Lung Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.1944
p.H521Q	SIDM01318	Hepatocellular Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.1944
p.H521Q	SIDM00641	Burkitt's Lymphoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.1944
p.V522I	SIDM00656	Burkitt's Lymphoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.2222
p.V522I	SIDM00277	Acute Myeloid Leukemia	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.2222
p.V522I	SIDM00694	Other Solid Cancers	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.2222
p.V522I	SIDM00049	Colorectal Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.2222
p.V522I	SIDM00309	Mesothelioma	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.2222
p.V522I	SIDM00930	Osteosarcoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.2222
p.V522I	SIDM00641	Burkitt's Lymphoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.2222
p.V522I	SIDM01387	Small Cell Lung Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.2222
p.E531D	SIDM01757	Bladder Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation altering degron motif	0.5647
p.A535V	SIDM01450	Gastric Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	526:531	Mutation rewiring degron network	0.2222

Kaplan plot for P2RX7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

P2RX7

UniProt ID: Q99572

Entrez ID: 5027

Protein name: P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for P2RX7 in