DegronMD

Uniprot ID: Q99572

Source protein: P2X purinoceptor 7

Source gene: P2RX7

Class: LIG_APCC_ABBA_1

Location: 526:531

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7964

ASA_SCORE: 49.3333

COIL: 0.2767

CONS_SCORE: 0.4908

DSS_SCORE: 0.0047

HELIX: 0.7115

FCONS_SCORE: 1.3315

RIG_SCORE: 0.9711

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E531K	TCGA-ZJ-AAXB	CESC	TCGA	LLLYQE	LIG_APCC_ABBA_1	0.7022
p.E531K	DO219753	CESC	ICGC	LLLYQE	LIG_APCC_ABBA_1	0.7022
p.F525L	DO46370	OV	ICGC	LLLYQE	LIG_APCC_ABBA_1	0.3056
p.H521Q	SIDM01265	Plasma Cell Myeloma	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.1944
p.H521Q	SIDM00773	Non-Cancerous	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.1944
p.H521Q	SIDM00845	Burkitt's Lymphoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.1944
p.H521Q	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.1944
p.H521Q	SIDM00969	Ovarian Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.1944
p.H521Q	SIDM00855	Other Sarcomas	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.1944
p.H521Q	SIDM00087	Plasma Cell Myeloma	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.1944
p.H521Q	SIDM00829	Acute Myeloid Leukemia	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.1944
p.H521Q	SIDM00633	Breast Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.1944
p.H521Q	SIDM00529	Breast Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.1944
p.H521Q	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.1944
p.H521Q	SIDM00863	Burkitt's Lymphoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.1944
p.H521Q	SIDM00721	Small Cell Lung Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.1944
p.H521Q	SIDM00774	Breast Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.1944
p.H521Q	SIDM00760	Small Cell Lung Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.1944
p.H521Q	SIDM01318	Hepatocellular Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.1944
p.H521Q	SIDM00641	Burkitt's Lymphoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.1944
p.V522I	SIDM00656	Burkitt's Lymphoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.2222
p.V522I	SIDM00277	Acute Myeloid Leukemia	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.2222
p.V522I	SIDM00694	Other Solid Cancers	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.2222
p.V522I	SIDM00049	Colorectal Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.2222
p.V522I	SIDM00309	Mesothelioma	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.2222
p.V522I	SIDM00930	Osteosarcoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.2222
p.V522I	SIDM00641	Burkitt's Lymphoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.2222
p.V522I	SIDM01387	Small Cell Lung Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.2222
p.E531D	SIDM01757	Bladder Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.5647
p.A535V	SIDM01450	Gastric Carcinoma	GDSC	LLLYQE	LIG_APCC_ABBA_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LLLYQE

Degron related mutations and impact score

Drug responses associated with P2RX7 mutations

All proteins holding degron of LLLYQE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99572	P2X purinoceptor 7	LIG_APCC_ABBA_1	526:531	LLLYQE	APC,CDC20,FZR1	0.7964	More...