TSC22D3
UniProt ID: Q99576
Entrez ID: 1831
Protein name: TSC22 domain family protein 3 (DSIP-immunoreactive peptide) (Protein DIP) (hDIP) (Delta sleep-inducing peptide immunoreactor) (Glucocorticoid-induced leucine zipper protein) (GILZ) (TSC-22-like protein) (TSC-22-related protein) (TSC-22R)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids an...
FUNCTION: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity). {ECO:0000250, ECO:0000269|PubMed:15031210}.
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GO - Biological processes (BP):
negative regulation of activation-induced cell death of T cells [GO:0070236]; regulation of transcription by RNA polymerase II [GO:0006357]; response to osmotic stress [GO:0006970]...
negative regulation of activation-induced cell death of T cells [GO:0070236]; regulation of transcription by RNA polymerase II [GO:0006357]; response to osmotic stress [GO:0006970]
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GO - Molecular function (MF):
...
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GO - Cellular component (CC):
cytosol [GO:0005829]; nucleus [GO:0005634]...
cytosol [GO:0005829]; nucleus [GO:0005634]
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TSC22D3
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Kaplan plot for TSC22D3 in
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*NOTE: the Kaplan plots were collected from OncoLnc