DegronMD

Uniprot ID: Q99576

Source protein: TSC22 domain family protein 3

Source gene: TSC22D3

Class: DEG_COP1_1

Location: 121:128

E3 ligase: COP1

DEGRON score: 0.8881

ASA_SCORE: 93.5

COIL: 0.9513

CONS_SCORE: 0.4565

DSS_SCORE: 0.8253

HELIX: 0.0198

FCONS_SCORE: 0.8915

RIG_SCORE: 0.5827

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E121K	TCGA-A5-A2K5	UCEC	TCGA	ESPQVPEA	DEG_COP1_1	0.7022
p.E121K	TCGA-AA-3984	COAD	TCGA	ESPQVPEA	DEG_COP1_1	0.7022
p.V113M	TCGA-EA-A3HU	CESC	TCGA	ESPQVPEA	DEG_COP1_1	0.1111
p.A134D	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ESPQVPEA	DEG_COP1_1	0.1667
p.A134D	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	ESPQVPEA	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99576	TSC22 domain family protein 3	DEG_COP1_1	121:128	ESPQVPEA	COP1	0.8881	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons