DegronMD - Q99674(CGREF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E190A	TCGA-2Z-A9JK	KIRP	TCGA	RRESLDPVQ	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.1111
p.E190A	DO219673	KIRP	ICGC	RRESLDPVQ	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.1111
p.G209E	TCGA-77-6844	LUSC	TCGA	RRESLDPVQ	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.25
p.G209E	DO26818	LUSC	ICGC	RRESLDPVQ	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.25
p.E200G	DO228542	GACA	ICGC	RRESLDPVQ	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.6087
p.E196D	DO23428	LINC	ICGC	RRESLDPVQ	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.2778
p.R199K	DO220855	MELA	ICGC	RRESLDPVQ	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.7237
p.V205F	SIDM02034	Colorectal Carcinoma	GDSC	RRESLDPVQ	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.7068
p.P208H	SIDM01113	Other Sarcomas	GDSC	RRESLDPVQ	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.2778
p.P208H	ACH-000939	Sarcoma	CCLE	RRESLDPVQ	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.2778
p.P208H	SK-UT-1	soft tissue	COSMIC	RRESLDPVQ	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.2778
p.Q194H	SIDM01551	Gastric Carcinoma	GDSC	RRESLDPVQ	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.2222
p.Q194H	ACH-000485	Gastric Cancer	CCLE	RRESLDPVQ	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.2222
p.D212G	786-0	kidney	COSMIC	RRESLDPVQ	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.1667
p.L202F	Mewo	skin	COSMIC	RRESLDPVQ	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.6981

Kaplan plot for CGREF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CGREF1

UniProt ID: Q99674

Entrez ID: 10669

Protein name: Cell growth regulator with EF hand domain protein 1 (Cell growth regulatory gene 11 protein) (Hydrophobestin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CGREF1 in