DegronMD

Uniprot ID: Q99674

Source protein: Cell growth regulator with EF hand domain protein 1

Source gene: CGREF1

Class: DEG_APCC_DBOX_1

Location: 198:206

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9792

ASA_SCORE: 112.4444

COIL: 0.781

CONS_SCORE: 0.4188

DSS_SCORE: 0.819

HELIX: 0.2052

FCONS_SCORE: 1.4263

RIG_SCORE: 0.6365

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E190A	TCGA-2Z-A9JK	KIRP	TCGA	RRESLDPVQ	DEG_APCC_DBOX_1	0.1111
p.E190A	DO219673	KIRP	ICGC	RRESLDPVQ	DEG_APCC_DBOX_1	0.1111
p.G209E	TCGA-77-6844	LUSC	TCGA	RRESLDPVQ	DEG_APCC_DBOX_1	0.25
p.G209E	DO26818	LUSC	ICGC	RRESLDPVQ	DEG_APCC_DBOX_1	0.25
p.E200G	DO228542	GACA	ICGC	RRESLDPVQ	DEG_APCC_DBOX_1	0.6087
p.E196D	DO23428	LINC	ICGC	RRESLDPVQ	DEG_APCC_DBOX_1	0.2778
p.R199K	DO220855	MELA	ICGC	RRESLDPVQ	DEG_APCC_DBOX_1	0.7237
p.V205F	SIDM02034	Colorectal Carcinoma	GDSC	RRESLDPVQ	DEG_APCC_DBOX_1	0.7068
p.P208H	SIDM01113	Other Sarcomas	GDSC	RRESLDPVQ	DEG_APCC_DBOX_1	0.2778
p.P208H	ACH-000939	Sarcoma	CCLE	RRESLDPVQ	DEG_APCC_DBOX_1	0.2778
p.P208H	SK-UT-1	soft_tissue	COSMIC	RRESLDPVQ	DEG_APCC_DBOX_1	0.2778
p.Q194H	SIDM01551	Gastric Carcinoma	GDSC	RRESLDPVQ	DEG_APCC_DBOX_1	0.2222
p.Q194H	ACH-000485	Gastric Cancer	CCLE	RRESLDPVQ	DEG_APCC_DBOX_1	0.2222
p.D212G	786-0	kidney	COSMIC	RRESLDPVQ	DEG_APCC_DBOX_1	0.1667
p.L202F	Mewo	skin	COSMIC	RRESLDPVQ	DEG_APCC_DBOX_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99674	Cell growth regulator with EF hand domain protein 1	DEG_APCC_DBOX_1	198:206	RRESLDPVQ	APC,CDC20,FZR1	0.9792	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons