DegronMD - Q99697(PITX2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K160E	TCGA-A8-A09Z	BRCA	TCGA	MQPYDD	LIG_APCC_ABBA_1	164:169	Mutation rewiring degron network	0.2222
p.D176V	TCGA-AP-A051	UCEC	TCGA	MQPYDD	LIG_APCC_ABBA_1	164:169	Mutation rewiring degron network	0.1389
p.L158Q	TCGA-BR-7715	STAD	TCGA	MQPYDD	LIG_APCC_ABBA_1	164:169	Mutation rewiring degron network	0.1667
p.E157K	TCGA-BS-A0UV	UCEC	TCGA	MQPYDD	LIG_APCC_ABBA_1	164:169	Mutation rewiring degron network	0.1389
p.P179Q	TCGA-DD-AADG	LIHC	TCGA	MQPYDD	LIG_APCC_ABBA_1	164:169	Mutation rewiring degron network	0.0556
p.D175N	TCGA-E6-A1LX	UCEC	TCGA	MQPYDD	LIG_APCC_ABBA_1	164:169	Mutation rewiring degron network	0.1667
p.F163L	TCGA-FS-A1ZN	SKCM	TCGA	MQPYDD	LIG_APCC_ABBA_1	164:169	Mutation rewiring degron network	0.3056
p.G162D	TCGA-QB-A6FS	SKCM	TCGA	MQPYDD	LIG_APCC_ABBA_1	164:169	Mutation rewiring degron network	0.2778
p.G164R	TCGA-W3-AA1V	SKCM	TCGA	MQPYDD	LIG_APCC_ABBA_1	164:169	Mutation altering degron motif	0.7568
p.S161G	DO219045	BLCA	ICGC	MQPYDD	LIG_APCC_ABBA_1	164:169	Mutation rewiring degron network	0.25
p.M176I	DO234406	ESAD	ICGC	MQPYDD	LIG_APCC_ABBA_1	164:169	Mutation rewiring degron network	0.1389
p.A169T	DO233871	GACA	ICGC	MQPYDD	LIG_APCC_ABBA_1	164:169	Mutation altering degron motif	0.7139
p.G166R	DO11046	GBM	ICGC	MQPYDD	LIG_APCC_ABBA_1	164:169	Mutation altering degron motif	0.7568
p.S166Y	DO228971	LICA	ICGC	MQPYDD	LIG_APCC_ABBA_1	164:169	Mutation altering degron motif	0.712
p.A173T	DO23440	LINC	ICGC	MQPYDD	LIG_APCC_ABBA_1	164:169	Mutation rewiring degron network	0.2222
p.N169S	DO219153	LUSC	ICGC	MQPYDD	LIG_APCC_ABBA_1	164:169	Mutation altering degron motif	0.7069
p.P168T	DO27104	LUSC	ICGC	MQPYDD	LIG_APCC_ABBA_1	164:169	Mutation altering degron motif	0.7031
p.V156I	DO49822	PRAD	ICGC	MQPYDD	LIG_APCC_ABBA_1	164:169	Mutation rewiring degron network	0.1111
p.S160P	DO219479	SKCM	ICGC	MQPYDD	LIG_APCC_ABBA_1	164:169	Mutation rewiring degron network	0.2222
p.S177W	DO38899	THCA	ICGC	MQPYDD	LIG_APCC_ABBA_1	164:169	Mutation rewiring degron network	0.1111
p.S177L	DO41008	UCEC	ICGC	MQPYDD	LIG_APCC_ABBA_1	164:169	Mutation rewiring degron network	0.1111
p.S163N	DO41871	UCEC	ICGC	MQPYDD	LIG_APCC_ABBA_1	164:169	Mutation rewiring degron network	0.3056
p.P165L	SIDM01943	Colorectal Carcinoma	GDSC	MQPYDD	LIG_APCC_ABBA_1	164:169	Mutation altering degron motif	0.7582
p.M176V	SNU-407	large intestine	COSMIC	MQPYDD	LIG_APCC_ABBA_1	164:169	Mutation rewiring degron network	0.1389

Kaplan plot for PITX2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PITX2

UniProt ID: Q99697

Entrez ID: 5308

Protein name: Pituitary homeobox 2 (ALL1-responsive protein ARP1) (Homeobox protein PITX2) (Paired-like homeodomain transcription factor 2) (RIEG bicoid-related homeobox transcription factor) (Solurshin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PITX2 in