DegronMD

Uniprot ID: Q99697

Source protein: Pituitary homeobox 2

Source gene: PITX2

Class: LIG_APCC_ABBA_1

Location: 164:169

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6318

ASA_SCORE: 40.5333

COIL: 0.8633

CONS_SCORE: 0.5751

DSS_SCORE: 0.2781

HELIX: 0.0718

FCONS_SCORE: 0.905

RIG_SCORE: 0.797

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K160E	TCGA-A8-A09Z	BRCA	TCGA	MQPYDD	LIG_APCC_ABBA_1	0.2222
p.D176V	TCGA-AP-A051	UCEC	TCGA	MQPYDD	LIG_APCC_ABBA_1	0.1389
p.L158Q	TCGA-BR-7715	STAD	TCGA	MQPYDD	LIG_APCC_ABBA_1	0.1667
p.E157K	TCGA-BS-A0UV	UCEC	TCGA	MQPYDD	LIG_APCC_ABBA_1	0.1389
p.P179Q	TCGA-DD-AADG	LIHC	TCGA	MQPYDD	LIG_APCC_ABBA_1	0.0556
p.D175N	TCGA-E6-A1LX	UCEC	TCGA	MQPYDD	LIG_APCC_ABBA_1	0.1667
p.F163L	TCGA-FS-A1ZN	SKCM	TCGA	MQPYDD	LIG_APCC_ABBA_1	0.3056
p.G162D	TCGA-QB-A6FS	SKCM	TCGA	MQPYDD	LIG_APCC_ABBA_1	0.2778
p.G164R	TCGA-W3-AA1V	SKCM	TCGA	MQPYDD	LIG_APCC_ABBA_1	0.7568
p.S161G	DO219045	BLCA	ICGC	MQPYDD	LIG_APCC_ABBA_1	0.25
p.M176I	DO234406	ESAD	ICGC	MQPYDD	LIG_APCC_ABBA_1	0.1389
p.A169T	DO233871	GACA	ICGC	MQPYDD	LIG_APCC_ABBA_1	0.7139
p.G166R	DO11046	GBM	ICGC	MQPYDD	LIG_APCC_ABBA_1	0.7568
p.S166Y	DO228971	LICA	ICGC	MQPYDD	LIG_APCC_ABBA_1	0.712
p.A173T	DO23440	LINC	ICGC	MQPYDD	LIG_APCC_ABBA_1	0.2222
p.N169S	DO219153	LUSC	ICGC	MQPYDD	LIG_APCC_ABBA_1	0.7069
p.P168T	DO27104	LUSC	ICGC	MQPYDD	LIG_APCC_ABBA_1	0.7031
p.V156I	DO49822	PRAD	ICGC	MQPYDD	LIG_APCC_ABBA_1	0.1111
p.S160P	DO219479	SKCM	ICGC	MQPYDD	LIG_APCC_ABBA_1	0.2222
p.S177W	DO38899	THCA	ICGC	MQPYDD	LIG_APCC_ABBA_1	0.1111
p.S177L	DO41008	UCEC	ICGC	MQPYDD	LIG_APCC_ABBA_1	0.1111
p.S163N	DO41871	UCEC	ICGC	MQPYDD	LIG_APCC_ABBA_1	0.3056
p.P165L	SIDM01943	Colorectal Carcinoma	GDSC	MQPYDD	LIG_APCC_ABBA_1	0.7582
p.M176V	SNU-407	large_intestine	COSMIC	MQPYDD	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99697	Pituitary homeobox 2	LIG_APCC_ABBA_1	164:169	MQPYDD	APC,CDC20,FZR1	0.6318	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons