DegronMD - Q99704(DOK1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R332Q	TCGA-A5-A0G1	UCEC	TCGA	KKPLYWD	LIG_APCC_ABBAyCdc20_2	333:339	Mutation rewiring degron network	0.3056
p.R332Q	DO42472	UCEC	ICGC	KKPLYWD	LIG_APCC_ABBAyCdc20_2	333:339	Mutation rewiring degron network	0.3056
p.E342G	TCGA-AA-A01P	COAD	TCGA	KKPLYWD	LIG_APCC_ABBAyCdc20_2	333:339	Mutation rewiring degron network	0.25
p.Q346K	TCGA-FD-A6TC	BLCA	TCGA	KKPLYWD	LIG_APCC_ABBAyCdc20_2	333:339	Mutation rewiring degron network	0.1389
p.Q346K	DO49755	BLCA	ICGC	KKPLYWD	LIG_APCC_ABBAyCdc20_2	333:339	Mutation rewiring degron network	0.1389
p.P335L	TCGA-FI-A2D5	UCEC	TCGA	KKPLYWD	LIG_APCC_ABBAyCdc20_2	333:339	Mutation altering degron motif	0.6471
p.A324G	TCGA-HC-7213	PRAD	TCGA	KKPLYWD	LIG_APCC_ABBAyCdc20_2	333:339	Mutation rewiring degron network	0.0833
p.T331N	DO222952	BTCA	ICGC	KKPLYWD	LIG_APCC_ABBAyCdc20_2	333:339	Mutation rewiring degron network	0.2778
p.V336I	DO10880	GBM	ICGC	KKPLYWD	LIG_APCC_ABBAyCdc20_2	333:339	Mutation altering degron motif	0.7076
p.G335V	DO26430	LUSC	ICGC	KKPLYWD	LIG_APCC_ABBAyCdc20_2	333:339	Mutation altering degron motif	0.7532
p.D323N	DO40051	THCA	ICGC	KKPLYWD	LIG_APCC_ABBAyCdc20_2	333:339	Mutation rewiring degron network	0.0556
p.Y341H	SIDM00971	Breast Carcinoma	GDSC	KKPLYWD	LIG_APCC_ABBAyCdc20_2	333:339	Mutation blocking phosphorylation signal	0.7222
p.Y341H	ACH-000828	Breast Cancer	CCLE	KKPLYWD	LIG_APCC_ABBAyCdc20_2	333:339	Mutation blocking phosphorylation signal	0.7222
p.Y341H	ZR-75-30	breast	COSMIC	KKPLYWD	LIG_APCC_ABBAyCdc20_2	333:339	Mutation blocking phosphorylation signal	0.7222
p.L349M	SIDM00039	Ovarian Carcinoma	GDSC	KKPLYWD	LIG_APCC_ABBAyCdc20_2	333:339	Mutation rewiring degron network	0.0556
p.D332A	TE-15	oesophagus	COSMIC	KKPLYWD	LIG_APCC_ABBAyCdc20_2	333:339	Mutation rewiring degron network	0.3056
p.D332A	AMO-1	haematopoietic and lymphoid tissue	COSMIC	KKPLYWD	LIG_APCC_ABBAyCdc20_2	333:339	Mutation rewiring degron network	0.3056
p.D332A	KP-4	pancreas	COSMIC	KKPLYWD	LIG_APCC_ABBAyCdc20_2	333:339	Mutation rewiring degron network	0.3056

Kaplan plot for DOK1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DOK1

UniProt ID: Q99704

Entrez ID: 1796

Protein name: Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DOK1 in