DegronMD

Uniprot ID: Q99704

Source protein: Docking protein 1

Source gene: DOK1

Class: LIG_APCC_ABBAyCdc20_2

Location: 333:339

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9773

ASA_SCORE: 86.4429

COIL: 0.8289

CONS_SCORE: 0.5035

DSS_SCORE: 0.3848

HELIX: 0.1063

FCONS_SCORE: 1.2536

RIG_SCORE: 0.8128

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R332Q	TCGA-A5-A0G1	UCEC	TCGA	KKPLYWD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R332Q	DO42472	UCEC	ICGC	KKPLYWD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E342G	TCGA-AA-A01P	COAD	TCGA	KKPLYWD	LIG_APCC_ABBAyCdc20_2	0.25
p.Q346K	TCGA-FD-A6TC	BLCA	TCGA	KKPLYWD	LIG_APCC_ABBAyCdc20_2	0.1389
p.Q346K	DO49755	BLCA	ICGC	KKPLYWD	LIG_APCC_ABBAyCdc20_2	0.1389
p.P335L	TCGA-FI-A2D5	UCEC	TCGA	KKPLYWD	LIG_APCC_ABBAyCdc20_2	0.6471
p.A324G	TCGA-HC-7213	PRAD	TCGA	KKPLYWD	LIG_APCC_ABBAyCdc20_2	0.0833
p.T331N	DO222952	BTCA	ICGC	KKPLYWD	LIG_APCC_ABBAyCdc20_2	0.2778
p.V336I	DO10880	GBM	ICGC	KKPLYWD	LIG_APCC_ABBAyCdc20_2	0.7076
p.G335V	DO26430	LUSC	ICGC	KKPLYWD	LIG_APCC_ABBAyCdc20_2	0.7532
p.D323N	DO40051	THCA	ICGC	KKPLYWD	LIG_APCC_ABBAyCdc20_2	0.0556
p.Y341H	SIDM00971	Breast Carcinoma	GDSC	KKPLYWD	LIG_APCC_ABBAyCdc20_2	0.7222
p.Y341H	ACH-000828	Breast Cancer	CCLE	KKPLYWD	LIG_APCC_ABBAyCdc20_2	0.7222
p.Y341H	ZR-75-30	breast	COSMIC	KKPLYWD	LIG_APCC_ABBAyCdc20_2	0.7222
p.L349M	SIDM00039	Ovarian Carcinoma	GDSC	KKPLYWD	LIG_APCC_ABBAyCdc20_2	0.0556
p.D332A	TE-15	oesophagus	COSMIC	KKPLYWD	LIG_APCC_ABBAyCdc20_2	0.3056
p.D332A	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	KKPLYWD	LIG_APCC_ABBAyCdc20_2	0.3056
p.D332A	KP-4	pancreas	COSMIC	KKPLYWD	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99704	Docking protein 1	LIG_APCC_ABBAyCdc20_2	333:339	KKPLYWD	APC,CDC20,FZR1	0.9773	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons