DegronMD - Q99750(MDFI)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R115W	TCGA-AJ-A3BG	UCEC	TCGA	DSGHPS	DEG_SCF_TRCP1_1	103:108	Mutation rewiring degron network	0.1389
p.R115W	TCGA-DU-6392	LGG	TCGA	DSGHPS	DEG_SCF_TRCP1_1	103:108	Mutation rewiring degron network	0.1389
p.P93L	TCGA-EE-A2GO	SKCM	TCGA	DSGHPS	DEG_SCF_TRCP1_1	103:108	Mutation rewiring degron network	0.0556
p.C113W	DO4233	BRCA	ICGC	DSGHPS	DEG_SCF_TRCP1_1	103:108	Mutation rewiring degron network	0.1944
p.C106Y	DO10582	COAD	ICGC	DSGHPS	DEG_SCF_TRCP1_1	103:108	Mutation altering degron motif	0.7087
p.E114D	DO229027	LICA	ICGC	DSGHPS	DEG_SCF_TRCP1_1	103:108	Mutation rewiring degron network	0.1667
p.L96I	DO232224	PBCA	ICGC	DSGHPS	DEG_SCF_TRCP1_1	103:108	Mutation rewiring degron network	0.1389
p.P95H	DO47374	SKCM	ICGC	DSGHPS	DEG_SCF_TRCP1_1	103:108	Mutation rewiring degron network	0.1111
p.P95H	ACH-001740	Sarcoma	CCLE	DSGHPS	DEG_SCF_TRCP1_1	103:108	Mutation rewiring degron network	0.1111
p.R115Q	SIDM01110	Hepatocellular Carcinoma	GDSC	DSGHPS	DEG_SCF_TRCP1_1	103:108	Mutation rewiring degron network	0.1389
p.R115Q	SIDM01076	B-Lymphoblastic Leukemia	GDSC	DSGHPS	DEG_SCF_TRCP1_1	103:108	Mutation rewiring degron network	0.1389
p.P98L	SIDM00431	T-Lymphoblastic Leukemia	GDSC	DSGHPS	DEG_SCF_TRCP1_1	103:108	Mutation rewiring degron network	0.1944
p.G112S	SIDM01336	Glioblastoma	GDSC	DSGHPS	DEG_SCF_TRCP1_1	103:108	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons