DegronMD

Uniprot ID: Q99750

Source protein: MyoD family inhibitor

Source gene: MDFI

Class: DEG_SCF_TRCP1_1

Location: 103:108

E3 ligase: BTRC

DEGRON score: 0.9702

ASA_SCORE: 73.0667

COIL: 0.9253

CONS_SCORE: 0.556

DSS_SCORE: 0.6772

HELIX: 0.0513

FCONS_SCORE: 0.9207

RIG_SCORE: 0.5927

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R115W	TCGA-AJ-A3BG	UCEC	TCGA	DSGHPS	DEG_SCF_TRCP1_1	0.1389
p.R115W	TCGA-DU-6392	LGG	TCGA	DSGHPS	DEG_SCF_TRCP1_1	0.1389
p.P93L	TCGA-EE-A2GO	SKCM	TCGA	DSGHPS	DEG_SCF_TRCP1_1	0.0556
p.C113W	DO4233	BRCA	ICGC	DSGHPS	DEG_SCF_TRCP1_1	0.1944
p.C106Y	DO10582	COAD	ICGC	DSGHPS	DEG_SCF_TRCP1_1	0.7087
p.E114D	DO229027	LICA	ICGC	DSGHPS	DEG_SCF_TRCP1_1	0.1667
p.L96I	DO232224	PBCA	ICGC	DSGHPS	DEG_SCF_TRCP1_1	0.1389
p.P95H	DO47374	SKCM	ICGC	DSGHPS	DEG_SCF_TRCP1_1	0.1111
p.P95H	ACH-001740	Sarcoma	CCLE	DSGHPS	DEG_SCF_TRCP1_1	0.1111
p.R115Q	SIDM01110	Hepatocellular Carcinoma	GDSC	DSGHPS	DEG_SCF_TRCP1_1	0.1389
p.R115Q	SIDM01076	B-Lymphoblastic Leukemia	GDSC	DSGHPS	DEG_SCF_TRCP1_1	0.1389
p.P98L	SIDM00431	T-Lymphoblastic Leukemia	GDSC	DSGHPS	DEG_SCF_TRCP1_1	0.1944
p.G112S	SIDM01336	Glioblastoma	GDSC	DSGHPS	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99750	MyoD family inhibitor	DEG_SCF_TRCP1_1	103:108	DSGHPS	BTRC	0.9702	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons