DegronMD - Q99757(TXN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q33H	TCGA-94-8491	LUSC	TCGA	LQTPQCS	DEG_SCF_FBW7_1	32:38	Mutation altering degron motif	0.647
p.Q33H	DO219174	LUSC	ICGC	LQTPQCS	DEG_SCF_FBW7_1	32:38	Mutation altering degron motif	0.647
p.P46L	TCGA-BW-A5NQ	LIHC	TCGA	LQTPQCS	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.1111
p.P46L	DO49659	LIHC	ICGC	LQTPQCS	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.1111
p.P39S	TCGA-CH-5768	PRAD	TCGA	LQTPQCS	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.3056
p.P39S	DO36353	PRAD	ICGC	LQTPQCS	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.3056
p.E27K	DO52483	COCA	ICGC	LQTPQCS	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.1944
p.Q23R	DO229208	THCA	ICGC	LQTPQCS	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.0833
p.S29P	ACH-000993	Endometrial/Uterine Cancer	CCLE	LQTPQCS	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.25
p.A30V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LQTPQCS	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.2778
p.A30V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	LQTPQCS	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.2778
p.N39Y	Mewo	skin	COSMIC	LQTPQCS	DEG_SCF_FBW7_1	32:38	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons