DegronMD

Uniprot ID: Q99757

Source protein: Thioredoxin, mitochondrial

Source gene: TXN2

Class: DEG_SCF_FBW7_1

Location: 32:38

E3 ligase: FBXW7

DEGRON score: 0.9106

ASA_SCORE: 76.9143

COIL: 0.8361

CONS_SCORE: 0.2144

DSS_SCORE: 0.5444

HELIX: 0.0651

FCONS_SCORE: 1.0049

RIG_SCORE: 0.6884

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q33H	TCGA-94-8491	LUSC	TCGA	LQTPQCS	DEG_SCF_FBW7_1	0.647
p.Q33H	DO219174	LUSC	ICGC	LQTPQCS	DEG_SCF_FBW7_1	0.647
p.P46L	TCGA-BW-A5NQ	LIHC	TCGA	LQTPQCS	DEG_SCF_FBW7_1	0.1111
p.P46L	DO49659	LIHC	ICGC	LQTPQCS	DEG_SCF_FBW7_1	0.1111
p.P39S	TCGA-CH-5768	PRAD	TCGA	LQTPQCS	DEG_SCF_FBW7_1	0.3056
p.P39S	DO36353	PRAD	ICGC	LQTPQCS	DEG_SCF_FBW7_1	0.3056
p.E27K	DO52483	COCA	ICGC	LQTPQCS	DEG_SCF_FBW7_1	0.1944
p.Q23R	DO229208	THCA	ICGC	LQTPQCS	DEG_SCF_FBW7_1	0.0833
p.S29P	ACH-000993	Endometrial/Uterine Cancer	CCLE	LQTPQCS	DEG_SCF_FBW7_1	0.25
p.A30V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LQTPQCS	DEG_SCF_FBW7_1	0.2778
p.A30V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LQTPQCS	DEG_SCF_FBW7_1	0.2778
p.N39Y	Mewo	skin	COSMIC	LQTPQCS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99757	Thioredoxin, mitochondrial	DEG_SCF_FBW7_1	32:38	LQTPQCS	FBXW7	0.9106	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons