DegronMD - Q99853(FOXB1)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A306T	TCGA-VQ-A91D	STAD	TCGA	PATPSET	DEG_SCF_FBW7_1	305:311	Mutation altering degron motif	0.6028
p.A306T	DO51783	STAD	ICGC	PATPSET	DEG_SCF_FBW7_1	305:311	Mutation altering degron motif	0.6028
p.S303I	DO228328	BRCA	ICGC	PATPSET	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.2778
p.A318T	DO218535	BTCA	ICGC	PATPSET	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.1389
p.T311M	DO234462	ESAD	ICGC	PATPSET	DEG_SCF_FBW7_1	305:311	Mutation altering degron motif	0.7423
p.S301I	DO228948	LICA	ICGC	PATPSET	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.2222
p.S317P	DO50739	LICA	ICGC	PATPSET	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.1667
p.S303R	DO229173	THCA	ICGC	PATPSET	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.2778
p.T300N	SIDM01545	Non-Small Cell Lung Carcinoma	GDSC	PATPSET	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.1944
p.A316V	SIDM01451	Pancreatic Carcinoma	GDSC	PATPSET	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.1944
p.A316V	ACH-000933	Pancreatic Cancer	CCLE	PATPSET	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons