DegronMD

Uniprot ID: Q99853

Source protein: Forkhead box protein B1

Source gene: FOXB1

Class: DEG_SCF_FBW7_1

Location: 305:311

E3 ligase: FBXW7

DEGRON score: 0.9976

ASA_SCORE: 72.5714

COIL: 0.8337

CONS_SCORE: 0.5253

DSS_SCORE: 0.6967

HELIX: 0.1351

FCONS_SCORE: 1.0626

RIG_SCORE: 0.5807

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T311M	DO234462	ESAD	ICGC	PATPSET	DEG_SCF_FBW7_1	0.7423
p.A306T	TCGA-VQ-A91D	STAD	TCGA	PATPSET	DEG_SCF_FBW7_1	0.6028
p.A306T	DO51783	STAD	ICGC	PATPSET	DEG_SCF_FBW7_1	0.6028
p.S303I	DO228328	BRCA	ICGC	PATPSET	DEG_SCF_FBW7_1	0.2778
p.S303R	DO229173	THCA	ICGC	PATPSET	DEG_SCF_FBW7_1	0.2778
p.S301I	DO228948	LICA	ICGC	PATPSET	DEG_SCF_FBW7_1	0.2222
p.T300N	SIDM01545	Non-Small Cell Lung Carcinoma	GDSC	PATPSET	DEG_SCF_FBW7_1	0.1944
p.A316V	SIDM01451	Pancreatic Carcinoma	GDSC	PATPSET	DEG_SCF_FBW7_1	0.1944
p.A316V	ACH-000933	Pancreatic Cancer	CCLE	PATPSET	DEG_SCF_FBW7_1	0.1944
p.S317P	DO50739	LICA	ICGC	PATPSET	DEG_SCF_FBW7_1	0.1667
p.A318T	DO218535	BTCA	ICGC	PATPSET	DEG_SCF_FBW7_1	0.1389

Showing 1 to 11 of 11 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99853	Forkhead box protein B1	DEG_SCF_FBW7_1	305:311	PATPSET	FBXW7	0.9976	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons