DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
PATPSET
Uniprot ID:
Q99853
Source protein:
Forkhead box protein B1
Source gene:
FOXB1
Class:
DEG_SCF_FBW7_1
Location:
305:311
E3 ligase:
FBXW7
DEGRON score:
0.9976
ASA_SCORE:
72.5714
COIL:
0.8337
CONS_SCORE:
0.5253
DSS_SCORE:
0.6967
HELIX:
0.1351
FCONS_SCORE:
1.0626
RIG_SCORE:
0.5807
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A306T
TCGA-VQ-A91D
STAD
TCGA
PATPSET
DEG_SCF_FBW7_1
0.6028
p.A306T
DO51783
STAD
ICGC
PATPSET
DEG_SCF_FBW7_1
0.6028
p.S303I
DO228328
BRCA
ICGC
PATPSET
DEG_SCF_FBW7_1
0.2778
p.A318T
DO218535
BTCA
ICGC
PATPSET
DEG_SCF_FBW7_1
0.1389
p.T311M
DO234462
ESAD
ICGC
PATPSET
DEG_SCF_FBW7_1
0.7423
p.S301I
DO228948
LICA
ICGC
PATPSET
DEG_SCF_FBW7_1
0.2222
p.S317P
DO50739
LICA
ICGC
PATPSET
DEG_SCF_FBW7_1
0.1667
p.S303R
DO229173
THCA
ICGC
PATPSET
DEG_SCF_FBW7_1
0.2778
p.T300N
SIDM01545
Non-Small Cell Lung Carcinoma
GDSC
PATPSET
DEG_SCF_FBW7_1
0.1944
p.A316V
SIDM01451
Pancreatic Carcinoma
GDSC
PATPSET
DEG_SCF_FBW7_1
0.1944
p.A316V
ACH-000933
Pancreatic Cancer
CCLE
PATPSET
DEG_SCF_FBW7_1
0.1944
Drug responses associated with FOXB1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PATPSET
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q99853
Forkhead box protein B1
DEG_SCF_FBW7_1
305:311
PATPSET
FBXW7
0.9976
More...