DegronMD - Q99944(EGFL8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R219P	TCGA-21-1081	LUSC	TCGA	LRGRLERLE	DEG_APCC_DBOX_1	218:226	Mutation altering degron motif	0.7512
p.R219P	DO26930	LUSC	ICGC	LRGRLERLE	DEG_APCC_DBOX_1	218:226	Mutation altering degron motif	0.7512
p.E223D	TCGA-A5-A0G2	UCEC	TCGA	LRGRLERLE	DEG_APCC_DBOX_1	218:226	Mutation altering degron motif	0.5647
p.E223D	DO41235	UCEC	ICGC	LRGRLERLE	DEG_APCC_DBOX_1	218:226	Mutation altering degron motif	0.5647
p.A210T	TCGA-BR-4292	STAD	TCGA	LRGRLERLE	DEG_APCC_DBOX_1	218:226	Mutation rewiring degron network	0.1111
p.A210T	DO38495	STAD	ICGC	LRGRLERLE	DEG_APCC_DBOX_1	218:226	Mutation rewiring degron network	0.1111
p.A210S	TCGA-HT-A5RC	LGG	TCGA	LRGRLERLE	DEG_APCC_DBOX_1	218:226	Mutation rewiring degron network	0.1111
p.A210S	DO48525	LGG	ICGC	LRGRLERLE	DEG_APCC_DBOX_1	218:226	Mutation rewiring degron network	0.1111
p.R209H	TCGA-WS-AB45	COAD	TCGA	LRGRLERLE	DEG_APCC_DBOX_1	218:226	Mutation rewiring degron network	0.0833
p.R209H	DO51734	COAD	ICGC	LRGRLERLE	DEG_APCC_DBOX_1	218:226	Mutation rewiring degron network	0.0833
p.G230S	SIDM01394	Kidney Carcinoma	GDSC	LRGRLERLE	DEG_APCC_DBOX_1	218:226	Mutation rewiring degron network	0.2222
p.G230S	ACH-000907	Kidney Cancer	CCLE	LRGRLERLE	DEG_APCC_DBOX_1	218:226	Mutation rewiring degron network	0.2222
p.G230D	SIDM01574	Plasma Cell Myeloma	GDSC	LRGRLERLE	DEG_APCC_DBOX_1	218:226	Mutation rewiring degron network	0.2222
p.G230D	ACH-000588	Myeloma	CCLE	LRGRLERLE	DEG_APCC_DBOX_1	218:226	Mutation rewiring degron network	0.2222
p.E226G	COLO-829	skin	COSMIC	LRGRLERLE	DEG_APCC_DBOX_1	218:226	Mutation altering degron motif	0.6087

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons