DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LRGRLERLE
Uniprot ID:
Q99944
Source protein:
Epidermal growth factor-like protein 8
Source gene:
EGFL8
Class:
DEG_APCC_DBOX_1
Location:
218:226
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6985
ASA_SCORE:
66.9444
COIL:
0.0709
CONS_SCORE:
0.5769
DSS_SCORE:
0.2654
HELIX:
0.9308
FCONS_SCORE:
1.2467
RIG_SCORE:
0.7958
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R219P
TCGA-21-1081
LUSC
TCGA
LRGRLERLE
DEG_APCC_DBOX_1
0.7512
p.R219P
DO26930
LUSC
ICGC
LRGRLERLE
DEG_APCC_DBOX_1
0.7512
p.E223D
TCGA-A5-A0G2
UCEC
TCGA
LRGRLERLE
DEG_APCC_DBOX_1
0.5647
p.E223D
DO41235
UCEC
ICGC
LRGRLERLE
DEG_APCC_DBOX_1
0.5647
p.A210T
TCGA-BR-4292
STAD
TCGA
LRGRLERLE
DEG_APCC_DBOX_1
0.1111
p.A210T
DO38495
STAD
ICGC
LRGRLERLE
DEG_APCC_DBOX_1
0.1111
p.A210S
TCGA-HT-A5RC
LGG
TCGA
LRGRLERLE
DEG_APCC_DBOX_1
0.1111
p.A210S
DO48525
LGG
ICGC
LRGRLERLE
DEG_APCC_DBOX_1
0.1111
p.R209H
TCGA-WS-AB45
COAD
TCGA
LRGRLERLE
DEG_APCC_DBOX_1
0.0833
p.R209H
DO51734
COAD
ICGC
LRGRLERLE
DEG_APCC_DBOX_1
0.0833
p.G230S
SIDM01394
Kidney Carcinoma
GDSC
LRGRLERLE
DEG_APCC_DBOX_1
0.2222
p.G230S
ACH-000907
Kidney Cancer
CCLE
LRGRLERLE
DEG_APCC_DBOX_1
0.2222
p.G230D
SIDM01574
Plasma Cell Myeloma
GDSC
LRGRLERLE
DEG_APCC_DBOX_1
0.2222
p.G230D
ACH-000588
Myeloma
CCLE
LRGRLERLE
DEG_APCC_DBOX_1
0.2222
p.E226G
COLO-829
skin
COSMIC
LRGRLERLE
DEG_APCC_DBOX_1
0.6087
Drug responses associated with EGFL8 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LRGRLERLE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q99944
Epidermal growth factor-like protein 8
DEG_APCC_DBOX_1
218:226
LRGRLERLE
APC,CDC20,FZR1
0.6985
More...