DegronMD

Uniprot ID: Q99944

Source protein: Epidermal growth factor-like protein 8

Source gene: EGFL8

Class: DEG_APCC_DBOX_1

Location: 218:226

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6985

ASA_SCORE: 66.9444

COIL: 0.0709

CONS_SCORE: 0.5769

DSS_SCORE: 0.2654

HELIX: 0.9308

FCONS_SCORE: 1.2467

RIG_SCORE: 0.7958

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R219P	TCGA-21-1081	LUSC	TCGA	LRGRLERLE	DEG_APCC_DBOX_1	0.7512
p.R219P	DO26930	LUSC	ICGC	LRGRLERLE	DEG_APCC_DBOX_1	0.7512
p.E226G	COLO-829	skin	COSMIC	LRGRLERLE	DEG_APCC_DBOX_1	0.6087
p.E223D	TCGA-A5-A0G2	UCEC	TCGA	LRGRLERLE	DEG_APCC_DBOX_1	0.5647
p.E223D	DO41235	UCEC	ICGC	LRGRLERLE	DEG_APCC_DBOX_1	0.5647
p.G230S	SIDM01394	Kidney Carcinoma	GDSC	LRGRLERLE	DEG_APCC_DBOX_1	0.2222
p.G230S	ACH-000907	Kidney Cancer	CCLE	LRGRLERLE	DEG_APCC_DBOX_1	0.2222
p.G230D	SIDM01574	Plasma Cell Myeloma	GDSC	LRGRLERLE	DEG_APCC_DBOX_1	0.2222
p.G230D	ACH-000588	Myeloma	CCLE	LRGRLERLE	DEG_APCC_DBOX_1	0.2222
p.A210T	TCGA-BR-4292	STAD	TCGA	LRGRLERLE	DEG_APCC_DBOX_1	0.1111
p.A210T	DO38495	STAD	ICGC	LRGRLERLE	DEG_APCC_DBOX_1	0.1111
p.A210S	TCGA-HT-A5RC	LGG	TCGA	LRGRLERLE	DEG_APCC_DBOX_1	0.1111
p.A210S	DO48525	LGG	ICGC	LRGRLERLE	DEG_APCC_DBOX_1	0.1111
p.R209H	TCGA-WS-AB45	COAD	TCGA	LRGRLERLE	DEG_APCC_DBOX_1	0.0833
p.R209H	DO51734	COAD	ICGC	LRGRLERLE	DEG_APCC_DBOX_1	0.0833

Showing 1 to 15 of 15 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99944	Epidermal growth factor-like protein 8	DEG_APCC_DBOX_1	218:226	LRGRLERLE	APC,CDC20,FZR1	0.6985	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons