DegronMD - Q9BPY3(FAM118B)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P24L	TCGA-10-0935	OV	TCGA	PRKLLPSLK	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.2222
p.P24L	DO28691	OV	ICGC	PRKLLPSLK	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.2222
p.V44L	TCGA-38-4626	LUAD	TCGA	PRKLLPSLK	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.1111
p.V44L	DO24447	LUAD	ICGC	PRKLLPSLK	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.1111
p.E22K	TCGA-AG-A002	READ	TCGA	PRKLLPSLK	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.1667
p.E22K	DO50434	ESAD	ICGC	PRKLLPSLK	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.1667
p.E42A	TCGA-BA-6869	HNSC	TCGA	PRKLLPSLK	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.1667
p.E42A	DO14250	HNSC	ICGC	PRKLLPSLK	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.1667
p.T37S	TCGA-D7-A4YT	STAD	TCGA	PRKLLPSLK	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.3056
p.T37S	DO47723	STAD	ICGC	PRKLLPSLK	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.3056
p.E42D	TCGA-JY-A93E	ESCA	TCGA	PRKLLPSLK	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.1667
p.P33S	TCGA-UZ-A9PS	KIRP	TCGA	PRKLLPSLK	DEG_APCC_DBOX_1	28:36	Mutation altering degron motif	0.5641
p.P33S	DO219709	KIRP	ICGC	PRKLLPSLK	DEG_APCC_DBOX_1	28:36	Mutation altering degron motif	0.5641
p.T37N	DO229275	THCA	ICGC	PRKLLPSLK	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons