DegronMD

Uniprot ID: Q9BPY3

Source protein: Protein FAM118B

Source gene: FAM118B

Class: DEG_APCC_DBOX_1

Location: 28:36

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7011

ASA_SCORE: 64.6778

COIL: 0.1931

CONS_SCORE: 0.9801

DSS_SCORE: 0.5536

HELIX: 0.8003

FCONS_SCORE: 1.2071

RIG_SCORE: 0.7642

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P24L	TCGA-10-0935	OV	TCGA	PRKLLPSLK	DEG_APCC_DBOX_1	0.2222
p.P24L	DO28691	OV	ICGC	PRKLLPSLK	DEG_APCC_DBOX_1	0.2222
p.V44L	TCGA-38-4626	LUAD	TCGA	PRKLLPSLK	DEG_APCC_DBOX_1	0.1111
p.V44L	DO24447	LUAD	ICGC	PRKLLPSLK	DEG_APCC_DBOX_1	0.1111
p.E22K	TCGA-AG-A002	READ	TCGA	PRKLLPSLK	DEG_APCC_DBOX_1	0.1667
p.E22K	DO50434	ESAD	ICGC	PRKLLPSLK	DEG_APCC_DBOX_1	0.1667
p.E42A	TCGA-BA-6869	HNSC	TCGA	PRKLLPSLK	DEG_APCC_DBOX_1	0.1667
p.E42A	DO14250	HNSC	ICGC	PRKLLPSLK	DEG_APCC_DBOX_1	0.1667
p.T37S	TCGA-D7-A4YT	STAD	TCGA	PRKLLPSLK	DEG_APCC_DBOX_1	0.3056
p.T37S	DO47723	STAD	ICGC	PRKLLPSLK	DEG_APCC_DBOX_1	0.3056
p.E42D	TCGA-JY-A93E	ESCA	TCGA	PRKLLPSLK	DEG_APCC_DBOX_1	0.1667
p.P33S	TCGA-UZ-A9PS	KIRP	TCGA	PRKLLPSLK	DEG_APCC_DBOX_1	0.5641
p.P33S	DO219709	KIRP	ICGC	PRKLLPSLK	DEG_APCC_DBOX_1	0.5641
p.T37N	DO229275	THCA	ICGC	PRKLLPSLK	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BPY3	Protein FAM118B	DEG_APCC_DBOX_1	28:36	PRKLLPSLK	APC,CDC20,FZR1	0.7011	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons