DegronMD - Q9BQ52(ELAC2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R190S	TCGA-05-4382	LUAD	TCGA	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation rewiring degron network	0.2778
p.R190S	DO24900	LUAD	ICGC	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation rewiring degron network	0.2778
p.P184H	TCGA-FS-A1ZB	SKCM	TCGA	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation altering degron motif	0.6583
p.P184H	DO37886	SKCM	ICGC	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation altering degron motif	0.6583
p.T179K	TCGA-FX-A76Y	SARC	TCGA	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation rewiring degron network	0.2222
p.H194Q	TCGA-PG-A917	UCEC	TCGA	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation rewiring degron network	0.1667
p.R191K	DO48566	BLCA	ICGC	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation rewiring degron network	0.25
p.V194A	DO5326	BRCA	ICGC	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation rewiring degron network	0.1667
p.E197K	DO233089	GACA	ICGC	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation rewiring degron network	0.0833
p.E197K	DO52101	HNSC	ICGC	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation rewiring degron network	0.0833
p.D195H	DO233249	GACA	ICGC	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation rewiring degron network	0.1389
p.S189N	DO233918	GACA	ICGC	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation rewiring degron network	0.3056
p.S189N	DO228867	LICA	ICGC	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation rewiring degron network	0.3056
p.P181T	DO228976	LICA	ICGC	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation blocking phosphorylation signal	0.7222
p.D195E	DO229026	LICA	ICGC	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation rewiring degron network	0.1389
p.D195E	DO229036	LICA	ICGC	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation rewiring degron network	0.1389
p.T179P	DO232761	PBCA	ICGC	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation rewiring degron network	0.2222
p.H175Q	DO52424	UCEC	ICGC	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation rewiring degron network	0.1111
p.E174K	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation rewiring degron network	0.0833
p.E174K	SIDM01210	Glioblastoma	GDSC	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation rewiring degron network	0.0833
p.E174K	SIDM00549	B-Lymphoblastic Leukemia	GDSC	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation rewiring degron network	0.0833
p.E174K	SIDM00381	Cervical Carcinoma	GDSC	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation rewiring degron network	0.0833
p.E174K	SIDM01460	Glioma	GDSC	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation rewiring degron network	0.0833
p.E174K	SIDM00016	Neuroblastoma	GDSC	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation rewiring degron network	0.0833
p.E174K	LC4-1	haematopoietic and lymphoid tissue	COSMIC	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation rewiring degron network	0.0833
p.E174K	KNS-81-FD	central nervous system	COSMIC	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation rewiring degron network	0.0833
p.E174K	KYSE-50	oesophagus	COSMIC	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation rewiring degron network	0.0833
p.E174K	SKG-IIIa	cervix	COSMIC	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation rewiring degron network	0.0833
p.R183S	NCI-H441	lung	COSMIC	IPIHSE	LIG_APCC_ABBA_1	183:188	Mutation altering degron motif	0.7427

Kaplan plot for ELAC2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ELAC2

UniProt ID: Q9BQ52

Entrez ID: 60528

Protein name: Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (ElaC homolog protein 2) (Heredity prostate cancer protein 2) (Ribonuclease Z 2) (RNase Z 2) (tRNA 3 endonuclease 2) (tRNase Z 2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ELAC2 in