DegronMD

Uniprot ID: Q9BQ52

Source protein: Zinc phosphodiesterase ELAC protein 2

Source gene: ELAC2

Class: LIG_APCC_ABBA_1

Location: 183:188

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9592

ASA_SCORE: 49.4667

COIL: 0.623

CONS_SCORE: 0.3247

DSS_SCORE: 0.5676

HELIX: 0.0675

FCONS_SCORE: 0.951

RIG_SCORE: 0.7329

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R190S	TCGA-05-4382	LUAD	TCGA	IPIHSE	LIG_APCC_ABBA_1	0.2778
p.R190S	DO24900	LUAD	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.2778
p.P184H	TCGA-FS-A1ZB	SKCM	TCGA	IPIHSE	LIG_APCC_ABBA_1	0.6583
p.P184H	DO37886	SKCM	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.6583
p.T179K	TCGA-FX-A76Y	SARC	TCGA	IPIHSE	LIG_APCC_ABBA_1	0.2222
p.H194Q	TCGA-PG-A917	UCEC	TCGA	IPIHSE	LIG_APCC_ABBA_1	0.1667
p.R191K	DO48566	BLCA	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.25
p.V194A	DO5326	BRCA	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.1667
p.E197K	DO233089	GACA	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.0833
p.E197K	DO52101	HNSC	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.0833
p.D195H	DO233249	GACA	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.1389
p.S189N	DO233918	GACA	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.3056
p.S189N	DO228867	LICA	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.3056
p.P181T	DO228976	LICA	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.7222
p.D195E	DO229026	LICA	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.1389
p.D195E	DO229036	LICA	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.1389
p.T179P	DO232761	PBCA	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.2222
p.H175Q	DO52424	UCEC	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.1111
p.E174K	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	IPIHSE	LIG_APCC_ABBA_1	0.0833
p.E174K	SIDM01210	Glioblastoma	GDSC	IPIHSE	LIG_APCC_ABBA_1	0.0833
p.E174K	SIDM00549	B-Lymphoblastic Leukemia	GDSC	IPIHSE	LIG_APCC_ABBA_1	0.0833
p.E174K	SIDM00381	Cervical Carcinoma	GDSC	IPIHSE	LIG_APCC_ABBA_1	0.0833
p.E174K	SIDM01460	Glioma	GDSC	IPIHSE	LIG_APCC_ABBA_1	0.0833
p.E174K	SIDM00016	Neuroblastoma	GDSC	IPIHSE	LIG_APCC_ABBA_1	0.0833
p.E174K	LC4-1	haematopoietic_and_lymphoid_tissue	COSMIC	IPIHSE	LIG_APCC_ABBA_1	0.0833
p.E174K	KNS-81-FD	central_nervous_system	COSMIC	IPIHSE	LIG_APCC_ABBA_1	0.0833
p.E174K	KYSE-50	oesophagus	COSMIC	IPIHSE	LIG_APCC_ABBA_1	0.0833
p.E174K	SKG-IIIa	cervix	COSMIC	IPIHSE	LIG_APCC_ABBA_1	0.0833
p.R183S	NCI-H441	lung	COSMIC	IPIHSE	LIG_APCC_ABBA_1	0.7427

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IPIHSE

Degron related mutations and impact score

Drug responses associated with ELAC2 mutations

All proteins holding degron of IPIHSE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQ52	Zinc phosphodiesterase ELAC protein 2	LIG_APCC_ABBA_1	183:188	IPIHSE	APC,CDC20,FZR1	0.9592	More...