DegronMD

Uniprot ID: Q9BQ52

Source protein: Zinc phosphodiesterase ELAC protein 2

Source gene: ELAC2

Class: LIG_APCC_ABBA_1

Location: 183:188

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9592

ASA_SCORE: 49.4667

COIL: 0.623

CONS_SCORE: 0.3247

DSS_SCORE: 0.5676

HELIX: 0.0675

FCONS_SCORE: 0.951

RIG_SCORE: 0.7329

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R183S	NCI-H441	lung	COSMIC	IPIHSE	LIG_APCC_ABBA_1	0.7427
p.P181T	DO228976	LICA	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.7222
p.P184H	TCGA-FS-A1ZB	SKCM	TCGA	IPIHSE	LIG_APCC_ABBA_1	0.6583
p.P184H	DO37886	SKCM	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.6583
p.S189N	DO233918	GACA	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.3056
p.S189N	DO228867	LICA	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.3056
p.R190S	TCGA-05-4382	LUAD	TCGA	IPIHSE	LIG_APCC_ABBA_1	0.2778
p.R190S	DO24900	LUAD	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.2778
p.R191K	DO48566	BLCA	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.25
p.T179K	TCGA-FX-A76Y	SARC	TCGA	IPIHSE	LIG_APCC_ABBA_1	0.2222
p.T179P	DO232761	PBCA	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.2222
p.H194Q	TCGA-PG-A917	UCEC	TCGA	IPIHSE	LIG_APCC_ABBA_1	0.1667
p.V194A	DO5326	BRCA	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.1667
p.D195H	DO233249	GACA	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.1389
p.D195E	DO229026	LICA	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.1389
p.D195E	DO229036	LICA	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.1389
p.H175Q	DO52424	UCEC	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.1111
p.E197K	DO233089	GACA	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.0833
p.E197K	DO52101	HNSC	ICGC	IPIHSE	LIG_APCC_ABBA_1	0.0833
p.E174K	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	IPIHSE	LIG_APCC_ABBA_1	0.0833
p.E174K	SIDM01210	Glioblastoma	GDSC	IPIHSE	LIG_APCC_ABBA_1	0.0833
p.E174K	SIDM00549	B-Lymphoblastic Leukemia	GDSC	IPIHSE	LIG_APCC_ABBA_1	0.0833
p.E174K	SIDM00381	Cervical Carcinoma	GDSC	IPIHSE	LIG_APCC_ABBA_1	0.0833
p.E174K	SIDM01460	Glioma	GDSC	IPIHSE	LIG_APCC_ABBA_1	0.0833
p.E174K	SIDM00016	Neuroblastoma	GDSC	IPIHSE	LIG_APCC_ABBA_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQ52	Zinc phosphodiesterase ELAC protein 2	LIG_APCC_ABBA_1	183:188	IPIHSE	APC,CDC20,FZR1	0.9592	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons