DegronMD - Q9BQ75(CMSS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R71M	TCGA-44-8117	LUAD	TCGA	RKENT	DEG_APCC_KENBOX_2	63:67	Mutation rewiring degron network	0.2222
p.R71M	DO24028	LUAD	ICGC	RKENT	DEG_APCC_KENBOX_2	63:67	Mutation rewiring degron network	0.2222
p.T67N	TCGA-D1-A17Q	UCEC	TCGA	RKENT	DEG_APCC_KENBOX_2	63:67	Mutation altering degron motif	0.5944
p.T67N	DO41903	UCEC	ICGC	RKENT	DEG_APCC_KENBOX_2	63:67	Mutation altering degron motif	0.5944
p.E65K	TCGA-DS-A5RQ	CESC	TCGA	RKENT	DEG_APCC_KENBOX_2	63:67	Mutation altering degron motif	0.7022
p.E65K	DO44392	CESC	ICGC	RKENT	DEG_APCC_KENBOX_2	63:67	Mutation altering degron motif	0.7022
p.K61N	DO8858	COAD	ICGC	RKENT	DEG_APCC_KENBOX_2	63:67	Mutation blocking ubiquitination signal	0.7222
p.K77N	DO228672	LICA	ICGC	RKENT	DEG_APCC_KENBOX_2	63:67	Mutation blocking ubiquitination signal	0.5
p.Q59R	SIDM00789	Colorectal Carcinoma	GDSC	RKENT	DEG_APCC_KENBOX_2	63:67	Mutation rewiring degron network	0.2222
p.Q59R	ACH-000997	Colon/Colorectal Cancer	CCLE	RKENT	DEG_APCC_KENBOX_2	63:67	Mutation rewiring degron network	0.2222
p.Q59R	ACH-001061	Colon/Colorectal Cancer	CCLE	RKENT	DEG_APCC_KENBOX_2	63:67	Mutation rewiring degron network	0.2222
p.Q59R	HCT-15	large intestine	COSMIC	RKENT	DEG_APCC_KENBOX_2	63:67	Mutation rewiring degron network	0.2222
p.E68Q	EMC-BAC-2	lung	COSMIC	RKENT	DEG_APCC_KENBOX_2	63:67	Mutation rewiring degron network	0.3056
p.E68Q	SW982	soft tissue	COSMIC	RKENT	DEG_APCC_KENBOX_2	63:67	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons