DegronMD

Uniprot ID: Q9BQ75

Source protein: Protein CMSS1

Source gene: CMSS1

Class: DEG_APCC_KENBOX_2

Location: 63:67

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6503

ASA_SCORE: 121.36

COIL: 0.7242

CONS_SCORE: 0.6231

DSS_SCORE: 0.6304

HELIX: 0.2764

FCONS_SCORE: 1.0199

RIG_SCORE: 0.6969

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R71M	TCGA-44-8117	LUAD	TCGA	RKENT	DEG_APCC_KENBOX_2	0.2222
p.R71M	DO24028	LUAD	ICGC	RKENT	DEG_APCC_KENBOX_2	0.2222
p.T67N	TCGA-D1-A17Q	UCEC	TCGA	RKENT	DEG_APCC_KENBOX_2	0.5944
p.T67N	DO41903	UCEC	ICGC	RKENT	DEG_APCC_KENBOX_2	0.5944
p.E65K	TCGA-DS-A5RQ	CESC	TCGA	RKENT	DEG_APCC_KENBOX_2	0.7022
p.E65K	DO44392	CESC	ICGC	RKENT	DEG_APCC_KENBOX_2	0.7022
p.K61N	DO8858	COAD	ICGC	RKENT	DEG_APCC_KENBOX_2	0.7222
p.K77N	DO228672	LICA	ICGC	RKENT	DEG_APCC_KENBOX_2	0.5
p.Q59R	SIDM00789	Colorectal Carcinoma	GDSC	RKENT	DEG_APCC_KENBOX_2	0.2222
p.Q59R	ACH-000997	Colon/Colorectal Cancer	CCLE	RKENT	DEG_APCC_KENBOX_2	0.2222
p.Q59R	ACH-001061	Colon/Colorectal Cancer	CCLE	RKENT	DEG_APCC_KENBOX_2	0.2222
p.Q59R	HCT-15	large_intestine	COSMIC	RKENT	DEG_APCC_KENBOX_2	0.2222
p.E68Q	EMC-BAC-2	lung	COSMIC	RKENT	DEG_APCC_KENBOX_2	0.3056
p.E68Q	SW982	soft_tissue	COSMIC	RKENT	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQ75	Protein CMSS1	DEG_APCC_KENBOX_2	63:67	RKENT	APC,CDC20,FZR1	0.6503	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons