DegronMD - Q9BQI7(PSD2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R230C	TCGA-44-4112	LUAD	TCGA	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.1667
p.R230C	DO26032	LUAD	ICGC	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.1667
p.R230H	TCGA-AP-A0LM	UCEC	TCGA	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.1667
p.R230H	TCGA-EY-A1GF	UCEC	TCGA	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.1667
p.R230H	DO50700	ORCA	ICGC	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.1667
p.R230H	DO43306	UCEC	ICGC	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.1667
p.R230H	DO41704	UCEC	ICGC	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.1667
p.G254S	TCGA-FW-A3R5	SKCM	TCGA	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.0556
p.G254S	DO37406	SKCM	ICGC	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.0556
p.S236I	TCGA-MH-A854	KIRP	TCGA	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation altering degron motif	0.623
p.S236I	DO49773	KIRP	ICGC	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation altering degron motif	0.623
p.R237H	TCGA-UY-A8OC	BLCA	TCGA	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation altering degron motif	0.8244
p.R237H	DO219038	BLCA	ICGC	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation altering degron motif	0.8244
p.R230L	DO228976	LICA	ICGC	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.1667
p.G246R	DO231712	LINC	ICGC	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.2778
p.R237C	DO222363	MELA	ICGC	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation altering degron motif	0.8301
p.R237C	SIDM01073	Other Blood Cancers	GDSC	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation altering degron motif	0.8301
p.N245S	SIDM00611	Kidney Carcinoma	GDSC	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.3056
p.N245S	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.3056
p.N245S	SIDM01575	Plasma Cell Myeloma	GDSC	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.3056
p.N245S	ACH-000426	Myeloma	CCLE	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.3056
p.N245S	ACH-000488	Esophageal Cancer	CCLE	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.3056
p.N245S	ACH-000684	Kidney Cancer	CCLE	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.3056
p.N245S	TE-11	oesophagus	COSMIC	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.3056
p.N245S	KMRC-1	kidney	COSMIC	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.3056
p.H248Y	SIDM01175	Other Sarcomas	GDSC	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.2222
p.H248Y	ACH-002309	Sarcoma	CCLE	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.2222
p.H248Y	SW684	soft tissue	COSMIC	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.2222
p.M241V	SIDM01154	T-Lymphoblastic Leukemia	GDSC	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation altering degron motif	0.6097
p.M241V	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation altering degron motif	0.6097
p.A242T	ACH-000738	Brain Cancer	CCLE	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation altering degron motif	0.6028
p.A242T	GB-1	central nervous system	COSMIC	SRLSLMAMP	DEG_APCC_DBOX_1	236:244	Mutation altering degron motif	0.6028

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PSD2

UniProt ID: Q9BQI7

Entrez ID: 84249

Protein name: PH and SEC7 domain-containing protein 2 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 C) (Exchange factor for ARF6 C) (Pleckstrin homology and SEC7 domain-containing protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PSD2 in