DegronMD

Uniprot ID: Q9BQI7

Source protein: PH and SEC7 domain-containing protein 2

Source gene: PSD2

Class: DEG_APCC_DBOX_1

Location: 236:244

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8549

ASA_SCORE: 83.8222

COIL: 0.5377

CONS_SCORE: 0.3217

DSS_SCORE: 0.5913

HELIX: 0.4152

FCONS_SCORE: 1.1274

RIG_SCORE: 0.6827

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R230C	TCGA-44-4112	LUAD	TCGA	SRLSLMAMP	DEG_APCC_DBOX_1	0.1667
p.R230C	DO26032	LUAD	ICGC	SRLSLMAMP	DEG_APCC_DBOX_1	0.1667
p.R230H	TCGA-AP-A0LM	UCEC	TCGA	SRLSLMAMP	DEG_APCC_DBOX_1	0.1667
p.R230H	TCGA-EY-A1GF	UCEC	TCGA	SRLSLMAMP	DEG_APCC_DBOX_1	0.1667
p.R230H	DO50700	ORCA	ICGC	SRLSLMAMP	DEG_APCC_DBOX_1	0.1667
p.R230H	DO43306	UCEC	ICGC	SRLSLMAMP	DEG_APCC_DBOX_1	0.1667
p.R230H	DO41704	UCEC	ICGC	SRLSLMAMP	DEG_APCC_DBOX_1	0.1667
p.G254S	TCGA-FW-A3R5	SKCM	TCGA	SRLSLMAMP	DEG_APCC_DBOX_1	0.0556
p.G254S	DO37406	SKCM	ICGC	SRLSLMAMP	DEG_APCC_DBOX_1	0.0556
p.S236I	TCGA-MH-A854	KIRP	TCGA	SRLSLMAMP	DEG_APCC_DBOX_1	0.623
p.S236I	DO49773	KIRP	ICGC	SRLSLMAMP	DEG_APCC_DBOX_1	0.623
p.R237H	TCGA-UY-A8OC	BLCA	TCGA	SRLSLMAMP	DEG_APCC_DBOX_1	0.8244
p.R237H	DO219038	BLCA	ICGC	SRLSLMAMP	DEG_APCC_DBOX_1	0.8244
p.R230L	DO228976	LICA	ICGC	SRLSLMAMP	DEG_APCC_DBOX_1	0.1667
p.G246R	DO231712	LINC	ICGC	SRLSLMAMP	DEG_APCC_DBOX_1	0.2778
p.R237C	DO222363	MELA	ICGC	SRLSLMAMP	DEG_APCC_DBOX_1	0.8301
p.R237C	SIDM01073	Other Blood Cancers	GDSC	SRLSLMAMP	DEG_APCC_DBOX_1	0.8301
p.N245S	SIDM00611	Kidney Carcinoma	GDSC	SRLSLMAMP	DEG_APCC_DBOX_1	0.3056
p.N245S	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	SRLSLMAMP	DEG_APCC_DBOX_1	0.3056
p.N245S	SIDM01575	Plasma Cell Myeloma	GDSC	SRLSLMAMP	DEG_APCC_DBOX_1	0.3056
p.N245S	ACH-000426	Myeloma	CCLE	SRLSLMAMP	DEG_APCC_DBOX_1	0.3056
p.N245S	ACH-000488	Esophageal Cancer	CCLE	SRLSLMAMP	DEG_APCC_DBOX_1	0.3056
p.N245S	ACH-000684	Kidney Cancer	CCLE	SRLSLMAMP	DEG_APCC_DBOX_1	0.3056
p.N245S	TE-11	oesophagus	COSMIC	SRLSLMAMP	DEG_APCC_DBOX_1	0.3056
p.N245S	KMRC-1	kidney	COSMIC	SRLSLMAMP	DEG_APCC_DBOX_1	0.3056
p.H248Y	SIDM01175	Other Sarcomas	GDSC	SRLSLMAMP	DEG_APCC_DBOX_1	0.2222
p.H248Y	ACH-002309	Sarcoma	CCLE	SRLSLMAMP	DEG_APCC_DBOX_1	0.2222
p.H248Y	SW684	soft_tissue	COSMIC	SRLSLMAMP	DEG_APCC_DBOX_1	0.2222
p.M241V	SIDM01154	T-Lymphoblastic Leukemia	GDSC	SRLSLMAMP	DEG_APCC_DBOX_1	0.6097
p.M241V	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	SRLSLMAMP	DEG_APCC_DBOX_1	0.6097
p.A242T	ACH-000738	Brain Cancer	CCLE	SRLSLMAMP	DEG_APCC_DBOX_1	0.6028
p.A242T	GB-1	central_nervous_system	COSMIC	SRLSLMAMP	DEG_APCC_DBOX_1	0.6028

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRLSLMAMP

Degron related mutations and impact score

Drug responses associated with PSD2 mutations

All proteins holding degron of SRLSLMAMP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQI7	PH and SEC7 domain-containing protein 2	DEG_APCC_DBOX_1	236:244	SRLSLMAMP	APC,CDC20,FZR1	0.8549	More...