DegronMD - Q9BQS7(HEPH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I791V	TCGA-05-4398	LUAD	TCGA	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.25
p.V796I	TCGA-05-5425	LUAD	TCGA	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.1111
p.H775Q	TCGA-29-1691	OV	TCGA	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.1389
p.P773T	TCGA-39-5036	LUSC	TCGA	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation substituting flanking lysine	0.1944
p.P773T	DO27508	LUSC	ICGC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation substituting flanking lysine	0.1944
p.C772Y	TCGA-AJ-A3EK	UCEC	TCGA	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.0556
p.C772Y	DO41584	UCEC	ICGC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.0556
p.R780H	TCGA-AP-A051	UCEC	TCGA	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.2778
p.R780H	DO42673	UCEC	ICGC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.2778
p.R780H	SIDM01724	Melanoma	GDSC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.2778
p.R782H	TCGA-AP-A051	UCEC	TCGA	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation altering degron motif	0.8244
p.R782H	TCGA-BS-A0UV	UCEC	TCGA	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation altering degron motif	0.8244
p.R787I	TCGA-AX-A2HC	UCEC	TCGA	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation altering degron motif	0.6991
p.I791T	TCGA-BR-8382	STAD	TCGA	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.25
p.A793T	TCGA-CK-5916	COAD	TCGA	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.1944
p.R790T	DO25985	LUAD	ICGC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.2778
p.F772L	DO51195	LUAD	ICGC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.0556
p.T796A	DO26650	LUSC	ICGC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.1111
p.R790W	DO229240	THCA	ICGC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.2778
p.G774R	SIDM00932	Kidney Carcinoma	GDSC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.1111
p.G774R	CAL-54	kidney	COSMIC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.1111
p.G774D	SIDM00518	Mesothelioma	GDSC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.1111
p.G774D	H290	pleura	COSMIC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.1111
p.P773H	SIDM00290	Gastric Carcinoma	GDSC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation substituting flanking lysine	0.1944
p.P773H	HGC-27	stomach	COSMIC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation substituting flanking lysine	0.1944
p.A777D	SIDM00603	Head and Neck Carcinoma	GDSC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.1944
p.A777D	KOSC-2	upper aerodigestive tract	COSMIC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.1944
p.R782C	SIDM01757	Bladder Carcinoma	GDSC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation altering degron motif	0.8301
p.R787M	ACH-000695	Lung Cancer	CCLE	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation altering degron motif	0.7521
p.D791Y	NCI-H1876	lung	COSMIC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.25
p.A786T	NCI-H630	large intestine	COSMIC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation altering degron motif	0.7139
p.F786V	Mewo	skin	COSMIC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation altering degron motif	0.7068
p.F789V	Mewo	skin	COSMIC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.3056
p.D794Y	NCI-H1876	lung	COSMIC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.1667
p.P772H	FADU	upper aerodigestive tract	COSMIC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	782:788	Mutation rewiring degron network	0.0556

Kaplan plot for HEPH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HEPH

UniProt ID: Q9BQS7

Entrez ID: 9843

Protein name: Hephaestin (EC 1.-.-.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HEPH in