DegronMD

Uniprot ID: Q9BQS7

Source protein: Hephaestin

Source gene: HEPH

Class: LIG_APCC_ABBAyCdc20_2

Location: 782:788

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7732

ASA_SCORE: 49.9714

COIL: 0.1631

CONS_SCORE: 0.5978

DSS_SCORE: 0.2437

HELIX: 0.0239

FCONS_SCORE: 1.3232

RIG_SCORE: 0.8422

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I791V	TCGA-05-4398	LUAD	TCGA	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.25
p.V796I	TCGA-05-5425	LUAD	TCGA	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.1111
p.H775Q	TCGA-29-1691	OV	TCGA	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P773T	TCGA-39-5036	LUSC	TCGA	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P773T	DO27508	LUSC	ICGC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.1944
p.C772Y	TCGA-AJ-A3EK	UCEC	TCGA	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.0556
p.C772Y	DO41584	UCEC	ICGC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R780H	TCGA-AP-A051	UCEC	TCGA	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R780H	DO42673	UCEC	ICGC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R780H	SIDM01724	Melanoma	GDSC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R782H	TCGA-AP-A051	UCEC	TCGA	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R782H	TCGA-BS-A0UV	UCEC	TCGA	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R787I	TCGA-AX-A2HC	UCEC	TCGA	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.6991
p.I791T	TCGA-BR-8382	STAD	TCGA	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.25
p.A793T	TCGA-CK-5916	COAD	TCGA	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R790T	DO25985	LUAD	ICGC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.2778
p.F772L	DO51195	LUAD	ICGC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.0556
p.T796A	DO26650	LUSC	ICGC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R790W	DO229240	THCA	ICGC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.2778
p.G774R	SIDM00932	Kidney Carcinoma	GDSC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G774R	CAL-54	kidney	COSMIC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G774D	SIDM00518	Mesothelioma	GDSC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G774D	H290	pleura	COSMIC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P773H	SIDM00290	Gastric Carcinoma	GDSC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P773H	HGC-27	stomach	COSMIC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A777D	SIDM00603	Head and Neck Carcinoma	GDSC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A777D	KOSC-2	upper_aerodigestive_tract	COSMIC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R782C	SIDM01757	Bladder Carcinoma	GDSC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.8301
p.R787M	ACH-000695	Lung Cancer	CCLE	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.7521
p.D791Y	NCI-H1876	lung	COSMIC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.25
p.A786T	NCI-H630	large_intestine	COSMIC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.7139
p.F786V	Mewo	skin	COSMIC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.7068
p.F789V	Mewo	skin	COSMIC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.3056
p.D794Y	NCI-H1876	lung	COSMIC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.P772H	FADU	upper_aerodigestive_tract	COSMIC	KKAVFRE	LIG_APCC_ABBAyCdc20_2	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KKAVFRE

Degron related mutations and impact score

Drug responses associated with HEPH mutations

All proteins holding degron of KKAVFRE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQS7	Hephaestin	LIG_APCC_ABBAyCdc20_2	782:788	KKAVFRE	APC,CDC20,FZR1	0.7732	More...