DegronMD - Q9BQT9(CLSTN3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P665T	TCGA-56-8622	LUSC	TCGA	VPLFPD	LIG_APCC_ABBA_1	664:669	Mutation altering degron motif	0.5919
p.P665T	TCGA-BG-A0LX	UCEC	TCGA	VPLFPD	LIG_APCC_ABBA_1	664:669	Mutation altering degron motif	0.5919
p.P665T	DO45449	LUSC	ICGC	VPLFPD	LIG_APCC_ABBA_1	664:669	Mutation altering degron motif	0.5919
p.P665T	DO41919	UCEC	ICGC	VPLFPD	LIG_APCC_ABBA_1	664:669	Mutation altering degron motif	0.5919
p.P668T	TCGA-AJ-A3BG	UCEC	TCGA	VPLFPD	LIG_APCC_ABBA_1	664:669	Mutation altering degron motif	0.5919
p.P668T	DO42633	UCEC	ICGC	VPLFPD	LIG_APCC_ABBA_1	664:669	Mutation altering degron motif	0.5919
p.E659D	TCGA-ER-A19N	SKCM	TCGA	VPLFPD	LIG_APCC_ABBA_1	664:669	Mutation rewiring degron network	0.1944
p.S675F	TCGA-EY-A1GH	UCEC	TCGA	VPLFPD	LIG_APCC_ABBA_1	664:669	Mutation rewiring degron network	0.1667
p.S675F	DO40972	UCEC	ICGC	VPLFPD	LIG_APCC_ABBA_1	664:669	Mutation rewiring degron network	0.1667
p.Q671K	TCGA-S4-A8RP	PAAD	TCGA	VPLFPD	LIG_APCC_ABBA_1	664:669	Mutation rewiring degron network	0.2778
p.R665H	DO233634	GACA	ICGC	VPLFPD	LIG_APCC_ABBA_1	664:669	Mutation altering degron motif	0.8244
p.R665H	DO224752	PACA	ICGC	VPLFPD	LIG_APCC_ABBA_1	664:669	Mutation altering degron motif	0.8244
p.H662N	DO20653	KIRC	ICGC	VPLFPD	LIG_APCC_ABBA_1	664:669	Mutation rewiring degron network	0.2778
p.P665S	DO222702	MELA	ICGC	VPLFPD	LIG_APCC_ABBA_1	664:669	Mutation altering degron motif	0.5641
p.E671D	DO37452	SKCM	ICGC	VPLFPD	LIG_APCC_ABBA_1	664:669	Mutation rewiring degron network	0.2778
p.S658R	DO51267	SKCM	ICGC	VPLFPD	LIG_APCC_ABBA_1	664:669	Mutation rewiring degron network	0.1667
p.A661T	DO42608	UCEC	ICGC	VPLFPD	LIG_APCC_ABBA_1	664:669	Mutation rewiring degron network	0.25
p.T661A	SIDM00082	Melanoma	GDSC	VPLFPD	LIG_APCC_ABBA_1	664:669	Mutation rewiring degron network	0.25
p.T661A	ACH-001190	Skin Cancer	CCLE	VPLFPD	LIG_APCC_ABBA_1	664:669	Mutation rewiring degron network	0.25
p.T661A	SK-MEL-2	skin	COSMIC	VPLFPD	LIG_APCC_ABBA_1	664:669	Mutation rewiring degron network	0.25
p.E659K	SIDM00013	Melanoma	GDSC	VPLFPD	LIG_APCC_ABBA_1	664:669	Mutation rewiring degron network	0.1944
p.E659K	ACH-002387	Skin Cancer	CCLE	VPLFPD	LIG_APCC_ABBA_1	664:669	Mutation rewiring degron network	0.1944
p.G663S	ACH-002680	Brain Cancer	CCLE	VPLFPD	LIG_APCC_ABBA_1	664:669	Mutation rewiring degron network	0.3056
p.T673A	SK-MEL-2	skin	COSMIC	VPLFPD	LIG_APCC_ABBA_1	664:669	Mutation rewiring degron network	0.2222
p.Q654K	SNU-175	large intestine	COSMIC	VPLFPD	LIG_APCC_ABBA_1	664:669	Mutation rewiring degron network	0.0556

Kaplan plot for CLSTN3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLSTN3

UniProt ID: Q9BQT9

Entrez ID: 9746

Protein name: Calsyntenin-3 (Alcadein-beta) (Alc-beta)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLSTN3 in