DegronMD

Uniprot ID: Q9BQT9

Source protein: Calsyntenin-3

Source gene: CLSTN3

Class: LIG_APCC_ABBA_1

Location: 664:669

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8998

ASA_SCORE: 55.6833

COIL: 0.6858

CONS_SCORE: 0.5532

DSS_SCORE: 0.2702

HELIX: 0.0277

FCONS_SCORE: 1.4159

RIG_SCORE: 0.8284

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P665T	TCGA-56-8622	LUSC	TCGA	VPLFPD	LIG_APCC_ABBA_1	0.5919
p.P665T	TCGA-BG-A0LX	UCEC	TCGA	VPLFPD	LIG_APCC_ABBA_1	0.5919
p.P665T	DO45449	LUSC	ICGC	VPLFPD	LIG_APCC_ABBA_1	0.5919
p.P665T	DO41919	UCEC	ICGC	VPLFPD	LIG_APCC_ABBA_1	0.5919
p.P668T	TCGA-AJ-A3BG	UCEC	TCGA	VPLFPD	LIG_APCC_ABBA_1	0.5919
p.P668T	DO42633	UCEC	ICGC	VPLFPD	LIG_APCC_ABBA_1	0.5919
p.E659D	TCGA-ER-A19N	SKCM	TCGA	VPLFPD	LIG_APCC_ABBA_1	0.1944
p.S675F	TCGA-EY-A1GH	UCEC	TCGA	VPLFPD	LIG_APCC_ABBA_1	0.1667
p.S675F	DO40972	UCEC	ICGC	VPLFPD	LIG_APCC_ABBA_1	0.1667
p.Q671K	TCGA-S4-A8RP	PAAD	TCGA	VPLFPD	LIG_APCC_ABBA_1	0.2778
p.R665H	DO233634	GACA	ICGC	VPLFPD	LIG_APCC_ABBA_1	0.8244
p.R665H	DO224752	PACA	ICGC	VPLFPD	LIG_APCC_ABBA_1	0.8244
p.H662N	DO20653	KIRC	ICGC	VPLFPD	LIG_APCC_ABBA_1	0.2778
p.P665S	DO222702	MELA	ICGC	VPLFPD	LIG_APCC_ABBA_1	0.5641
p.E671D	DO37452	SKCM	ICGC	VPLFPD	LIG_APCC_ABBA_1	0.2778
p.S658R	DO51267	SKCM	ICGC	VPLFPD	LIG_APCC_ABBA_1	0.1667
p.A661T	DO42608	UCEC	ICGC	VPLFPD	LIG_APCC_ABBA_1	0.25
p.T661A	SIDM00082	Melanoma	GDSC	VPLFPD	LIG_APCC_ABBA_1	0.25
p.T661A	ACH-001190	Skin Cancer	CCLE	VPLFPD	LIG_APCC_ABBA_1	0.25
p.T661A	SK-MEL-2	skin	COSMIC	VPLFPD	LIG_APCC_ABBA_1	0.25
p.E659K	SIDM00013	Melanoma	GDSC	VPLFPD	LIG_APCC_ABBA_1	0.1944
p.E659K	ACH-002387	Skin Cancer	CCLE	VPLFPD	LIG_APCC_ABBA_1	0.1944
p.G663S	ACH-002680	Brain Cancer	CCLE	VPLFPD	LIG_APCC_ABBA_1	0.3056
p.T673A	SK-MEL-2	skin	COSMIC	VPLFPD	LIG_APCC_ABBA_1	0.2222
p.Q654K	SNU-175	large_intestine	COSMIC	VPLFPD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQT9	Calsyntenin-3	LIG_APCC_ABBA_1	664:669	VPLFPD	APC,CDC20,FZR1	0.8998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons