DegronMD - Q9BQW3(EBF4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S524P	TCGA-AA-A010	COAD	TCGA	APTTS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.0833
p.S538L	TCGA-B5-A0JY	UCEC	TCGA	APTTS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.3056
p.S538L	DO43041	UCEC	ICGC	APTTS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.3056
p.A545T	DO222842	COCA	ICGC	APTTS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.1111
p.A545T	DO222739	ESCA	ICGC	APTTS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.1111
p.A524G	DO229016	COCA	ICGC	APTTS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.0833
p.P543T	DO234160	ESAD	ICGC	APTTS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.1667
p.P543S	DO48682	LIRI	ICGC	APTTS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.1667
p.M527L	DO47140	RECA	ICGC	APTTS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.1667
p.S524A	DO37439	SKCM	ICGC	APTTS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.0833
p.A434V	SIDM02039	Colorectal Carcinoma	GDSC	LAPSHPHPAVVGI	DEG_ODPH_VHL_1	418:430	Mutation rewiring degron network	0.2222
p.S536F	SIDM00241	Breast Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.7982
p.S536F	OCUB-M	breast	COSMIC	APTTS	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.7982
p.A529V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	APTTS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.2222
p.A529V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	APTTS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.2222
p.G413W	ACH-000623	Brain Cancer	CCLE	LAPSHPHPAVVGI	DEG_ODPH_VHL_1	418:430	Mutation rewiring degron network	0.1944
p.P423S	ACH-000822	Skin Cancer	CCLE	LAPSHPHPAVVGI	DEG_ODPH_VHL_1	418:430	Mutation altering degron motif	0.5641
p.A533V	ACH-001127	Leukemia	CCLE	APTTS	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.5825
p.A533V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	APTTS	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.5825
p.S540F	ACH-002179	Breast Cancer	CCLE	APTTS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.25
p.S540F	OCUB-M	breast	COSMIC	APTTS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.25

Kaplan plot for EBF4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EBF4

UniProt ID: Q9BQW3

Entrez ID: 57593

Protein name: Transcription factor COE4 (Early B-cell factor 4) (EBF-4) (Olf-1/EBF-like 4) (O/E-4) (OE-4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EBF4 in