DegronMD

Uniprot ID: Q9BQW3

Source protein: Transcription factor COE4

Source gene: EBF4

Class: DEG_ODPH_VHL_1

Location: 418:430

E3 ligase: VHL

DEGRON score: 0.9428

ASA_SCORE: 70.1923

COIL: 0.8134

CONS_SCORE: 0.2949

DSS_SCORE: 0.3762

HELIX: 0.0669

FCONS_SCORE: 0.8483

RIG_SCORE: 0.6649

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A434V	SIDM02039	Colorectal Carcinoma	GDSC	LAPSHPHPAVVGI	DEG_ODPH_VHL_1	0.2222
p.G413W	ACH-000623	Brain Cancer	CCLE	LAPSHPHPAVVGI	DEG_ODPH_VHL_1	0.1944
p.P423S	ACH-000822	Skin Cancer	CCLE	LAPSHPHPAVVGI	DEG_ODPH_VHL_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQW3	Transcription factor COE4	DEG_ODPH_VHL_1	418:430	LAPSHPHPAVVGI	VHL	0.9428	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons