DegronMD - Q9BR39(JPH2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G150W	TCGA-A5-A1OF	UCEC	TCGA	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.0833
p.G150W	DO42568	UCEC	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.0833
p.V153M	TCGA-A6-5666	COAD	TCGA	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.1667
p.V153M	DO9482	COAD	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.1667
p.P177S	TCGA-AP-A1DK	UCEC	TCGA	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.0556
p.P177S	DO42033	UCEC	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.0556
p.S164L	TCGA-BG-A2L7	UCEC	TCGA	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.7667
p.S164L	DO220879	MELA	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.7667
p.S164L	DO42344	UCEC	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.7667
p.T161M	TCGA-EO-A3B0	UCEC	TCGA	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.6312
p.T161M	DO219773	UCEC	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.6312
p.R160C	TCGA-FI-A2D0	UCEC	TCGA	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.8301
p.R160C	DO43891	UCEC	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.8301
p.R160C	SIDM02039	Colorectal Carcinoma	GDSC	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.8301
p.R160C	ACH-000939	Sarcoma	CCLE	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.8301
p.P158L	TCGA-R6-A6DQ	ESCA	TCGA	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.3056
p.V153G	DO48382	BLCA	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.1667
p.G150R	DO2509	BRCA	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.0833
p.R156H	DO233239	GACA	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.25
p.V175M	DO233276	GACA	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.1111
p.P158Q	DO229029	LICA	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.3056
p.A152D	DO229026	LICA	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.1389
p.R167H	DO230529	LUSC	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.7133
p.R167S	DO26971	LUSC	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.6316
p.S157L	DO49418	PACA	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation blocking phosphorylation signal	0.7222
p.A176V	DO47268	SKCM	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.0833
p.G150E	DO37439	SKCM	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.0833
p.R160H	SIDM02013	Colorectal Carcinoma	GDSC	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.8244
p.T174K	ACH-001521	Skin Cancer	CCLE	LRTSLSSLR	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.1389

Kaplan plot for JPH2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

JPH2

UniProt ID: Q9BR39

Entrez ID: 57158

Protein name: Junctophilin-2 (JP-2) (Junctophilin type 2) [Cleaved into: Junctophilin-2 N-terminal fragment (JP2NT)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for JPH2 in