DegronMD

Uniprot ID: Q9BR39

Source protein: Junctophilin-2

Source gene: JPH2

Class: DEG_APCC_DBOX_1

Location: 159:167

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8553

ASA_SCORE: 65.2222

COIL: 0.353

CONS_SCORE: 0.413

DSS_SCORE: 0.4967

HELIX: 0.0179

FCONS_SCORE: 1.1219

RIG_SCORE: 0.6958

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G150W	TCGA-A5-A1OF	UCEC	TCGA	LRTSLSSLR	DEG_APCC_DBOX_1	0.0833
p.G150W	DO42568	UCEC	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	0.0833
p.V153M	TCGA-A6-5666	COAD	TCGA	LRTSLSSLR	DEG_APCC_DBOX_1	0.1667
p.V153M	DO9482	COAD	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	0.1667
p.P177S	TCGA-AP-A1DK	UCEC	TCGA	LRTSLSSLR	DEG_APCC_DBOX_1	0.0556
p.P177S	DO42033	UCEC	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	0.0556
p.S164L	TCGA-BG-A2L7	UCEC	TCGA	LRTSLSSLR	DEG_APCC_DBOX_1	0.7667
p.S164L	DO220879	MELA	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	0.7667
p.S164L	DO42344	UCEC	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	0.7667
p.T161M	TCGA-EO-A3B0	UCEC	TCGA	LRTSLSSLR	DEG_APCC_DBOX_1	0.6312
p.T161M	DO219773	UCEC	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	0.6312
p.R160C	TCGA-FI-A2D0	UCEC	TCGA	LRTSLSSLR	DEG_APCC_DBOX_1	0.8301
p.R160C	DO43891	UCEC	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	0.8301
p.R160C	SIDM02039	Colorectal Carcinoma	GDSC	LRTSLSSLR	DEG_APCC_DBOX_1	0.8301
p.R160C	ACH-000939	Sarcoma	CCLE	LRTSLSSLR	DEG_APCC_DBOX_1	0.8301
p.P158L	TCGA-R6-A6DQ	ESCA	TCGA	LRTSLSSLR	DEG_APCC_DBOX_1	0.3056
p.V153G	DO48382	BLCA	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	0.1667
p.G150R	DO2509	BRCA	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	0.0833
p.R156H	DO233239	GACA	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	0.25
p.V175M	DO233276	GACA	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	0.1111
p.P158Q	DO229029	LICA	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	0.3056
p.A152D	DO229026	LICA	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	0.1389
p.R167H	DO230529	LUSC	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	0.7133
p.R167S	DO26971	LUSC	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	0.6316
p.S157L	DO49418	PACA	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	0.7222
p.A176V	DO47268	SKCM	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	0.0833
p.G150E	DO37439	SKCM	ICGC	LRTSLSSLR	DEG_APCC_DBOX_1	0.0833
p.R160H	SIDM02013	Colorectal Carcinoma	GDSC	LRTSLSSLR	DEG_APCC_DBOX_1	0.8244
p.T174K	ACH-001521	Skin Cancer	CCLE	LRTSLSSLR	DEG_APCC_DBOX_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRTSLSSLR

Degron related mutations and impact score

Drug responses associated with JPH2 mutations

All proteins holding degron of LRTSLSSLR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BR39	Junctophilin-2	DEG_APCC_DBOX_1	159:167	LRTSLSSLR	APC,CDC20,FZR1	0.8553	More...