DegronMD - Q9BR61(ACBD6)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S15G	TCGA-A5-A1OF	UCEC	TCGA	DSGGELS	DEG_SCF_TRCP1_1	14:20	Mutation altering degron motif	0.6993
p.S15G	DO42568	UCEC	ICGC	DSGGELS	DEG_SCF_TRCP1_1	14:20	Mutation altering degron motif	0.6993
p.S20N	TCGA-DU-6407	LGG	TCGA	DSGGELS	DEG_SCF_TRCP1_1	14:20	Mutation altering degron motif	0.7069
p.S20N	DO22295	LGG	ICGC	DSGGELS	DEG_SCF_TRCP1_1	14:20	Mutation altering degron motif	0.7069
p.A8T	TCGA-X6-A8C3	SARC	TCGA	DSGGELS	DEG_SCF_TRCP1_1	14:20	Mutation rewiring degron network	0.1667
p.A8T	DO220320	SARC	ICGC	DSGGELS	DEG_SCF_TRCP1_1	14:20	Mutation rewiring degron network	0.1667
p.V28G	DO49172	PACA	ICGC	DSGGELS	DEG_SCF_TRCP1_1	14:20	Mutation rewiring degron network	0.1111

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons