DegronMD

Uniprot ID: Q9BR61

Source protein: Acyl-CoA-binding domain-containing protein 6

Source gene: ACBD6

Class: DEG_SCF_TRCP1_1

Location: 14:20

E3 ligase: BTRC

DEGRON score: 0.9774

ASA_SCORE: 58.8571

COIL: 0.8553

CONS_SCORE: 0.4383

DSS_SCORE: 0.6688

HELIX: 0.0507

FCONS_SCORE: 1.045

RIG_SCORE: 0.5648

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S15G	TCGA-A5-A1OF	UCEC	TCGA	DSGGELS	DEG_SCF_TRCP1_1	0.6993
p.S15G	DO42568	UCEC	ICGC	DSGGELS	DEG_SCF_TRCP1_1	0.6993
p.S20N	TCGA-DU-6407	LGG	TCGA	DSGGELS	DEG_SCF_TRCP1_1	0.7069
p.S20N	DO22295	LGG	ICGC	DSGGELS	DEG_SCF_TRCP1_1	0.7069
p.A8T	TCGA-X6-A8C3	SARC	TCGA	DSGGELS	DEG_SCF_TRCP1_1	0.1667
p.A8T	DO220320	SARC	ICGC	DSGGELS	DEG_SCF_TRCP1_1	0.1667
p.V28G	DO49172	PACA	ICGC	DSGGELS	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BR61	Acyl-CoA-binding domain-containing protein 6	DEG_SCF_TRCP1_1	14:20	DSGGELS	BTRC	0.9774	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons