DegronMD - Q9BRJ6(C7orf50)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P178S	TCGA-FS-A1ZK	SKCM	TCGA	IRQVLQLLS	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1111
p.P178S	DO37474	SKCM	ICGC	IRQVLQLLS	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1111
p.R187Q	TCGA-ZX-AA5X	CESC	TCGA	IRQVLQLLS	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.7329
p.R187Q	DO219762	CESC	ICGC	IRQVLQLLS	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.7329
p.P180T	DO229035	LICA	ICGC	IRQVLQLLS	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1667
p.P177A	DO220912	MELA	ICGC	IRQVLQLLS	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.0833
p.R185C	DO43763	UCEC	ICGC	IRQVLQLLS	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.3056
p.D176N	SIDM01127	Non-Small Cell Lung Carcinoma	GDSC	IRQVLQLLS	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.0556
p.D176N	ACH-000628	Lung Cancer	CCLE	IRQVLQLLS	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.0556
p.P178R	SIDM00205	Ewing's Sarcoma	GDSC	IRQVLQLLS	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1111
p.P178R	ACH-002110	Bone Cancer	CCLE	IRQVLQLLS	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1111
p.P180L	SIDM00359	Colorectal Carcinoma	GDSC	IRQVLQLLS	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1667
p.P178L	ACH-000945	Lung Cancer	CCLE	IRQVLQLLS	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons